(19)
(11) EP 0 898 564 A1

(12)

(43) Date of publication:
03.03.1999 Bulletin 1999/09

(21) Application number: 97920379.0

(22) Date of filing: 14.04.1997
(51) International Patent Classification (IPC): 
C07D 213/ 34( . )
(86) International application number:
PCT/US1997/006131
(87) International publication number:
WO 1997/038976 (23.10.1997 Gazette 1997/45)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE
Designated Extension States:
RO

(30) Priority: 17.04.1996 US 19960015687
10.06.1996 GB 19960012083

(71) Applicant: MERCK & CO., INC.
Rahway, New Jersey 07065 (US)

(72) Inventors:
  • HOUPIS, Ioannis
    Rahway, NJ 07065 (US)
  • MOLINA, Audrey
    Rahway, NJ 07065 (US)
  • VOLANTE, Ralph, P.
    Rahway, NJ 07065 (US)

(74) Representative: Horgan, James Michael Frederic, et al 
Merck & Co., Inc., Terlings Park, Eastwick Road
Harlow, Essex CM20 2QR
Harlow, Essex CM20 2QR (GB)

   


(54) METHOD OF PREPARING PHOSPHODIESTERASE IV INHIBITORS