(19)

(11)

EP 0 898 569 A1

(12)

(43) Date of publication: 03.03.1999 Bulletin 1999/09 (21) Application number: 97920673.0 (22) Date of filing: 14.04.1997

(51) International Patent Classification (IPC):  C07D 211/ 14( . ) A61K 31/ 40( . ) A61K 31/ 404( . ) A61K 31/ 4427( . ) A61K 31/ 4439( . ) A61K 31/ 4465( . ) A61K 31/ 454( . ) A61K 31/ 55( . ) A61P 43/ 00( . ) C07D 401/ 04( . ) C07D 401/ 12( . ) C07D 403/ 04( . ) C07D 405/ 14( . ) A61K 31/ 00( . ) A61K 31/ 403( . ) A61K 31/ 44( . ) A61K 31/ 443( . ) A61K 31/ 445( . ) A61K 31/ 4523( . ) A61K 31/ 4545( . ) A61P 25/ 04( . ) C07D 207/ 06( . ) C07D 401/ 06( . ) C07D 401/ 14( . ) C07D 405/ 04( . ) (86) International application number: PCT/EP1997/001853 (87) International publication number: WO 1997/040038 (30.10.1997 Gazette 1997/46)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 18.04.1996 DE 19961015232 (71) Applicant: MERCK PATENT GmbH 64293 Darmstadt (DE)

(72) Inventors: MÄRZ, Joachim D-55128 Mainz (DE) BÖTTCHER, Henning D-64287 Darmstadt (DE) DEVANT, Ralf D-64291 Darmstadt (DE) GREINER, Hartmut D-64331 Weiterstadt (DE) BARTOSZYK, Gerd D-64331 Weiterstadt (DE) HARTING, Jürgen D-64287 Darmstadt (DE) SEYFRIED, Christoph D-64342 Seeheim-Jugenheim (DE) BENGT, Ronny, Andersson S-413 26 Göteborg (SE) HANSSON, Lars, Olov S-414 64 Göteborg (SE) SONESSON, Clas, Ake S-427 34 Billdal (SE) STJERNLÖF, Nils, Peter S-426 69 V Fröliinda (SE)