(19)
(11) EP 0 900 201 A1

(12)

(43) Date of publication:
10.03.1999 Bulletin 1999/10

(21) Application number: 97917190.0

(22) Date of filing: 22.04.1997
(51) International Patent Classification (IPC): 
A61K 31/ 00( . )
A61K 31/ 4402( . )
A61K 31/ 4409( . )
A61P 11/ 06( . )
A61P 15/ 06( . )
A61P 19/ 10( . )
A61P 27/ 00( . )
A61P 27/ 06( . )
A61P 35/ 00( . )
A61P 37/ 00( . )
C07D 213/ 50( . )
C07D 213/ 64( . )
A61K 31/ 44( . )
A61K 31/ 4406( . )
A61P 11/ 00( . )
A61P 15/ 00( . )
A61P 19/ 00( . )
A61P 25/ 28( . )
A61P 27/ 02( . )
A61P 29/ 00( . )
A61P 35/ 04( . )
A61P 43/ 00( . )
C07D 213/ 61( . )
(86) International application number:
PCT/CA1997/000270
(87) International publication number:
WO 1997/040012 (30.10.1997 Gazette 1997/46)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

(30) Priority: 23.04.1996 US 19960016076P
30.04.1996 GB 19960008813

(71) Applicant: MERCK FROSST CANADA INC.
Kirkland Quebec H9H 3L1 (CA)

(72) Inventors:
  • BLACK, Cameron
    Kirkland, Quebec H9H 3L1 (CA)
  • HUGHES, Greg
    Kirkland, Quebec H9H 3L1 (CA)
  • WANG, Zhaoyin
    Kirkland, Quebec H9H 3L1 (CA)

(74) Representative: Horgan, James Michael Frederic, et al 
Merck & Co., Inc., Terlings Park, Eastwick Road
Harlow, Essex CM20 2QR
Harlow, Essex CM20 2QR (GB)

   


(54) PYRIDINYL-2-CYCLOPENTEN-1-ONES AS SELECTIVE CYCLOOXYGENASE-2 INHIBITORS