(19)
(11) EP 0 900 286 A1

(12)

(43) Date of publication:
10.03.1999 Bulletin 1999/10

(21) Application number: 97916941.0

(22) Date of filing: 03.04.1997
(51) International Patent Classification (IPC): 
G01N 33/ 53( . )
C12Q 1/ 68( . )
C12N 15/ 09( . )
G01N 33/ 566( . )
(86) International application number:
PCT/US1997/004710
(87) International publication number:
WO 1997/040189 (30.10.1997 Gazette 1997/46)
(84) Designated Contracting States:
CH DE ES FR GB IT LI NL SE

(30) Priority: 19.04.1996 US 19960015634P
22.04.1996 US 19960015877P

(71) Applicants:
  • PHARMACIA & UPJOHN COMPANY
    Kalamazoo, Michigan 49001 (US)
  • Nycomed Amersham plc
    Cardiff CF4 7YT (GB)

(72) Inventors:
  • JONES, David, A.
    Kalamazoo, MI 49008 (US)
  • HARRIS, Douglas, W.
    Portage, MI 49002 (US)
  • KENRICK, Michael K.
    Caerphilly CF83 1SG (GB)
  • THOMAS, Nicholas
    Cardiff CF4 8RU (GB)

(74) Representative: Rollins, Anthony John, et al 
Group Patents, Nycomed Amersham plc, White Lion Road
Amersham, Buckinghamshire HP7 9LL
Amersham, Buckinghamshire HP7 9LL (GB)

   


(54) HIGH VOLUME IN-SITU mRNA HYBRIDIZATION METHOD FOR THE QUANTIFICATION AND DISCOVERY OF DISEASE SPECIFIC GENES