(19)

(11)

EP 0 901 484 A1

(12)

(43) Date of publication: 17.03.1999 Bulletin 1999/11 (21) Application number: 97924720.0 (22) Date of filing: 05.05.1997

(51) International Patent Classification (IPC):  C07D 317/ 68( . ) A61K 31/ 357( . ) A61K 31/ 42( . ) A61P 3/ 00( . ) A61P 3/ 10( . ) C07D 407/ 14( . ) C07D 413/ 06( . ) A61K 31/ 00( . ) A61K 31/ 36( . ) A61K 31/ 422( . ) A61P 3/ 04( . ) C07D 317/ 46( . ) C07D 409/ 14( . ) C07F 7/ 18( . ) (86) International application number: PCT/US1997/008148 (87) International publication number: WO 1997/043273 (20.11.1997 Gazette 1997/50)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV RO SI (30) Priority: 14.05.1996 US 19960645970 (71) Applicant: AMERICAN HOME PRODUCTS CORPORATION Madison, New Jersey 07940-0874 (US)

(72) Inventors: GILBERT, Adam, Matthew Valley Cottage, NY 10989 (US) GROSU, George, Theodore Pearl River, NY 10965 (US) MALAMAS, Michael, Sotirios Jamison, PA 18929 (US) SUM, Fuk-Wah Pomona, NY 10970 (US) VENKATESAN, Aranapakam Mudumbai Rego Park, NY 11374 (US) FRANCISCO, Gerardo De la Cruz Orangeburg, NY 10962 (US) (74) Representative: Wileman, David Francis, et al  c/o John Wyeth and Brother Limited Huntercombe Lane South Taplow Maidenhead Berkshire SL6 OPH Taplow Maidenhead Berkshire SL6 OPH (GB)