| (19) |
 |
|
(11) |
EP 0 901 786 A3 |
| (12) |
EUROPEAN PATENT APPLICATION |
| (88) |
Date of publication A3: |
|
19.01.2000 Bulletin 2000/03 |
| (43) |
Date of publication A2: |
|
17.03.1999 Bulletin 1999/11 |
| (22) |
Date of filing: 27.07.1998 |
|
|
| (84) |
Designated Contracting States: |
|
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
Designated Extension States: |
|
AL LT LV MK RO SI |
| (30) |
Priority: |
11.08.1997 US 55221 P
|
| (71) |
Applicant: Pfizer Products Inc. |
|
Groton, CT 06340-5146 (US) |
|
| (72) |
Inventors: |
|
- Curatolo, William John
Niantic, Connecticut 06357 (US)
- Herbig, Scott Max
East Lyme, Connecticut 06333 (US)
- Nightingale, James Alan Schriver
Bend, Oregon 97701 (US)
|
| (74) |
Representative: Hayles, James Richard et al |
|
Pfizer Limited, Patents Department, Ramsgate Road
Sandwich Kent CT13 9NJ
Sandwich Kent CT13 9NJ (GB) |
|
| |
|
| (54) |
Solid pharmaceutical dispersions with enhanced bioavailability |
(57) Spray dried solid dispersions comprising a sparingly soluble drug and hydroxypropylmethylcellulose
acetate succinate (HPMCAS) provide increased aqueous solubility and/or biavailability
in a use environment.