(19)

(11)

EP 0 902 837 A1

(12)

(43) Date of publication: 24.03.1999 Bulletin 1999/12 (21) Application number: 97950312.0 (22) Date of filing: 23.12.1997

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 39/ 00( . ) A61P 25/ 04( . ) A61P 37/ 02( . ) C07K 16/ 28( . ) C12N 15/ 12( . ) G01N 33/ 15( . ) G01N 33/ 566( . ) A61K 38/ 00( . ) A61K 31/ 00( . ) A61K 39/ 395( . ) A61P 37/ 00( . ) C07K 14/ 705( . ) C12N 1/ 21( . ) C12Q 1/ 02( . ) G01N 33/ 50( . ) G01N 33/ 68( . ) C12R 1/ 19( . ) (86) International application number: PCT/GB1997/003526 (87) International publication number: WO 1998/028418 (02.07.1998 Gazette 1998/26)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.12.1996 GB 19960026699 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford, Middlesex TW8 9EP (GB)

(72) Inventors: BEELEY, Lee, James, SmithKline Beecham Pharm. Harlow, Essex CM19 5AW (GB) JENKINS, Owen, SmithKline Beecham Pharm. Harlow, Essex CM19 5AW (GB) MOSSAKOWSKA, Danuta, E. I., SmithKline BeechamPh.m Harlow, Essex CM19 5AW (GB) (74) Representative: Connell, Anthony Christopher, et al  SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)