(19)

(11)

EP 0 904 067 A1

(12)

(43) Date of publication: 31.03.1999 Bulletin 1999/13 (21) Application number: 97915801.0 (22) Date of filing: 21.03.1997

(51) International Patent Classification (IPC):  A61K 47/ 40( . ) A61K 31/ 485( . ) A61K 9/ 70( . ) (86) International application number: PCT/SE1997/000484 (87) International publication number: WO 1997/039742 (30.10.1997 Gazette 1997/46)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 23.04.1996 SE 19960001528 (71) Applicant: Pharmacia & Upjohn Aktiebolag 112 87 Stockholm (SE)	(72) Inventors: HOECK, Ulla DK-3400 Hilleröd (DK) KREILGARD, Bo DK-3400 Hilleröd (DK) KRISTENSEN, Helle DK-3550 Slangerup (DK) (74) Representative: Hedenström, John Allan, et al  Pharmacia & Upjohn AB, Patent Department, P.O. Box 941 251 09 Helsingborg 251 09 Helsingborg (SE)