(19)

(11)

EP 0 904 103 A1

(12)

(43) Date of publication: 31.03.1999 Bulletin 1999/13 (21) Application number: 97918782.0 (22) Date of filing: 18.04.1997

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 31/ 70( . ) A61K 35/ 76( . ) A61K 39/ 00( . ) A61P 37/ 00( . ) C07H 21/ 02( . ) C07K 16/ 40( . ) C12N 9/ 10( . ) G01N 33/ 15( . ) A61K 31/ 00( . ) A61K 31/ 7088( . ) A61K 38/ 00( . ) A61K 48/ 00( . ) A61P 37/ 02( . ) C07H 21/ 04( . ) C12N 9/ 00( . ) C12Q 1/ 48( . ) G01N 33/ 50( . ) (86) International application number: PCT/US1997/006753 (87) International publication number: WO 1997/038718 (23.10.1997 Gazette 1997/45)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 18.04.1996 GB 19960007992 (71) Applicants: SMITHKLINE BEECHAM CORPORATION Philadelphia Pennsylvania 19103 (US) SMITHKLINE BEECHAM PLC Brentford, Middlesex TW8 9EP (GB)	(72) Inventor: LAWLOR, Elizabeth, Jane Malvern, PA 19355 (US) (74) Representative: Mallalieu, Catherine Louise  D. Young & Co., 21 New Fetter Lane London EC4A 1DA London EC4A 1DA (GB)