(19)

(11)

EP 0 904 387 A1

(12)

(43) Date of publication: 31.03.1999 Bulletin 1999/13 (21) Application number: 96920791.0 (22) Date of filing: 04.06.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A01N 65/ 00( . ) C07K 14/ 415( . ) C12N 15/ 11( . ) C12N 15/ 82( . ) A01H 5/ 00( . ) A01P 5/ 00( . ) C12N 5/ 10( . ) C12N 15/ 29( . ) (86) International application number: PCT/EP1996/002437 (87) International publication number: WO 1997/046692 (11.12.1997 Gazette 1998/01)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: MOGEN INTERNATIONAL N.V. NL-2333 CB Leiden (NL)	(72) Inventors: OHL, Stephan, Andreas NL-2331 JP Leiden (NL) SIJMONS, Peter, Christiaan NL-1075 GK Amsterdam (NL) VAN DER LEE, Frédérique, Marianne NL-2623 GJ Delft (NL) GODDIJN, Oscar, Johannes, Maria NL-2312 LN Leiden (NL) KLAP, Joke NL-1055 NA Amsterdam (NL) (74) Representative: van Wezenbeek, Lambertus A.C.M.  Mogen International n.v. PO Box 628 2300 AP Leiden 2300 AP Leiden (NL)