(19)

(11)

EP 0 906 117 A1

(12)

(43) Date of publication: 07.04.1999 Bulletin 1999/14 (21) Application number: 97921343.0 (22) Date of filing: 01.05.1997

(51) International Patent Classification (IPC):  A61K 38/ 00( . ) A61K 38/ 20( . ) A61P 9/ 10( . ) A61K 31/ 00( . ) A61P 9/ 00( . ) (86) International application number: PCT/US1997/006809 (87) International publication number: WO 1997/040849 (06.11.1997 Gazette 1997/47)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: LT LV RO (30) Priority: 02.05.1996 US 19960641859 (71) Applicant: Shering Corporation Kenilworth, NJ 07033 (US)	(72) Inventors: SEEGER, James, M. Gainesville, FL 32605 (US) HARWARD, Timothy, R., S. Gainesville, FL 32608 (US) NARULA, Satwant, K. West Caldwell, NJ 07006 (US) MOLDAWER, Lyle, L. Gainesville, FL 32605 (US) (74) Representative: Ritter, Stephen David, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)