(19)

(11)

EP 0 907 734 A2

(12)

(43) Date of publication: 14.04.1999 Bulletin 1999/15 (21) Application number: 97929814.0 (22) Date of filing: 05.06.1997

(51) International Patent Classification (IPC):  G01N 33/ 50( . ) C12N 1/ 15( . ) C12N 1/ 21( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) G01N 33/ 566( . ) C07K 14/ 72( . ) C12N 1/ 19( . ) C12N 5/ 10( . ) C12N 15/ 12( . ) G01N 33/ 15( . ) A61K 38/ 00( . ) (86) International application number: PCT/US1997/009787 (87) International publication number: WO 1997/046681 (11.12.1997 Gazette 1998/01)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.06.1996 US A 665034 03.06.1997 US A 868034 (71) Applicant: Bayer Corporation Pittsburgh, PA 15205-9741 (US)	(72) Inventors: BLOOMQUIST, Brian, T. New Haven, CT 06515 (US) McCALEB, Michael, L. Thousand Oaks, CA 91362 (US) CORNFIELD, Linda, J. Hamden, CT 06518 (US) YOO-WARREN, Heeja Boulder, CO 80304 (US) (74) Representative: Burkert, Frank  Bayer AG, Konzernbereich RP Patente und Lizenzen 51368 Leverkusen 51368 Leverkusen (DE)