(19)

(11)

EP 0 907 744 A1

(12)

(43) Date of publication: 14.04.1999 Bulletin 1999/15 (21) Application number: 97928160.0 (22) Date of filing: 05.06.1997

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C12N 9/ 62( . ) C12N 15/ 80( . ) C12N 1/ 15( . ) C12N 15/ 57( . ) (86) International application number: PCT/EP1997/002982 (87) International publication number: WO 1997/046689 (11.12.1997 Gazette 1998/01)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 05.06.1996 EP 19960201579 (71) Applicant: GIST-BROCADES B.V. 2600 MA Delft (NL)	(72) Inventors: VAN DEN HOMBERGH, Johannes Petrus Theodorus W. NL-3523 GP Utrecht (NL) VISSER, Jacob NL-6708 PK Wageningen (NL) (74) Representative: Swinkels, Bart Willem, et al  Gist-brocades B.V., Patents & Trademarks, P.O. Box 1 2600 MA Delft 2600 MA Delft (NL)