(19)

(11)

EP 0 909 165 A1

(12)

(43) Date of publication: 21.04.1999 Bulletin 1999/16 (21) Application number: 97927347.0 (22) Date of filing: 01.07.1997

(51) International Patent Classification (IPC):  A61K 9/ 127( . ) (86) International application number: PCT/IE1997/000044 (87) International publication number: WO 1998/000112 (08.01.1998 Gazette 1998/01)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 02.07.1996 IE 19960000485 (71) Applicants: UNIVERSITY COLLEGE DUBLIN Dublin 4 (IE) Rochev, Jury Pushchino, Moscow Region 142292 (RU)	(72) Inventors: DAWSON, Kenneth Adrian Dublin 4 (IE) GORELOV, Alexander Vladimirovich Dublin 14 (IE) Rochev, Jury Inst.of Theoretical and Experimental Region 142292 (RU) (74) Representative: Ryan, Anne Mary, et al  c/o Anne Ryan & Co. 60 Northumberland Road Ballsbridge Dublin 4 Ballsbridge Dublin 4 (IE)