(19)

(11)

EP 0 909 273 A1

(12)

(43) Date of publication: 21.04.1999 Bulletin 1999/16 (21) Application number: 97929144.0 (22) Date of filing: 07.07.1997

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 38/ 27( . ) A61K 38/ 43( . ) C07K 14/ 575( . ) C12N 1/ 15( . ) C12N 1/ 21( . ) C12N 9/ 20( . ) C12R 1/ 66( . ) A61K 38/ 00( . ) A61K 38/ 28( . ) C07K 14/ 38( . ) C07K 14/ 745( . ) C12N 1/ 19( . ) C12N 9/ 00( . ) C12N 15/ 80( . ) (86) International application number: PCT/DK1997/000305 (87) International publication number: WO 1998/001470 (15.01.1998 Gazette 1998/02)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI NL PT SE (30) Priority: 05.07.1996 DK 19960000740 (60) Divisional application: 05109743.4 / 1616580 (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)	(72) Inventor: CHRISTENSEN, Tove DK-2880 Bagsvaerd (DK) (74) Representative: Ryberg, Lise Abildgaard, et al  c/o Novo Nordisk A/S, Corporate Patents, Novo Allé 2880 Bagsvaerd 2880 Bagsvaerd (DK)