(19)

(11)

EP 0 909 321 A2

(12)

(43) Date of publication: 21.04.1999 Bulletin 1999/16 (21) Application number: 97932238.0 (22) Date of filing: 02.07.1997

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C07K 14/ 715( . ) C12N 1/ 15( . ) C12N 1/ 21( . ) C12N 15/ 19( . ) C07K 14/ 52( . ) C07K 16/ 24( . ) C12N 1/ 19( . ) C12N 5/ 10( . ) (86) International application number: PCT/US1997/010819 (87) International publication number: WO 1998/001557 (15.01.1998 Gazette 1998/02)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: LT LV RO (30) Priority: 05.07.1996 US 19960675814 11.10.1996 US 19960028329P 04.06.1997 US 19970048593P (71) Applicant: SCHERING CORPORATION Kenilworth New Jersey 07033 (US)	(72) Inventors: GISH, Kurt, C. San Francisco, CA 94117 (US) SCHALL, Thomas, J. Menlo Park, CA 94025 (US) VICARI, Alain Mountain View, CA 94087 (US) ZLOTNIK, Albert Palo Alto, CA 94306 (US) WANG, Wei Palo Alto, CA 94306 (US) (74) Representative: Ritter, Stephen David, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)