| (19) |
 |
|
(11) |
EP 0 909 558 A3 |
| (12) |
EUROPEAN PATENT APPLICATION |
| (88) |
Date of publication A3: |
|
27.10.1999 Bulletin 1999/43 |
| (43) |
Date of publication A2: |
|
21.04.1999 Bulletin 1999/16 |
| (22) |
Date of filing: 24.08.1998 |
|
|
| (84) |
Designated Contracting States: |
|
AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE |
|
Designated Extension States: |
|
AL LT LV MK RO SI |
| (30) |
Priority: |
29.08.1997 JP 233990/97
|
| (71) |
Applicants: |
|
- SANTEN PHARMACEUTICAL CO., LTD.
Higashiyodogawa-ku,
Osaka-shi,
Osaka 533-8651 (JP)
- SANWA KAGAKU KENKYUSHO CO., LTD.
Higashi-ku
Nagoya-shi
Aichi-ken 461 (JP)
|
|
| (72) |
Inventors: |
|
- Ota, Atsutoshi
c/o Santen Pharmaceutical Co., Ltd
Ikoma-shi
Nara 630-01 (JP)
- Kuwano, Mitsuaki
c/o Santen Pharmaceutical Co.,LTD
Ikoma-shi
Nara 630-01 (JP)
- Takada, Koichi
c/o Santen Pharmaceutical Co.,LTD.
Ikoma-shi
Nara 630-01 (JP)
- Hibi, Chihiro
c/o Sanwa Kagaku Kenkyusho Co.,Ltd.
Nagoya-shi
Aichi 461 (JP)
|
| (74) |
Representative: Paul, Dieter-Alfred, Dipl.-Ing. et al |
|
Fichtestrasse 18
41464 Neuss
41464 Neuss (DE) |
|
| |
|
| (54) |
Chroman derivative containing ophthalmic solution |
(57) The object of the present invention is to provide an ophthalmic solution with improvement
in the ocular penetration of (2S, 4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide
as an active ingredient. The ophthalmic solution of the present invention comprises
(2S, 4S)-6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide as an
active ingredient wherein the osmotic pressure ratio is adjusted to less than 1 and
the viscosity to more than 1 cP thereby ocular penetration of the active ingredient
are remarkably improved. As a viscosity increasing agent, a cellulose-based polymer
for example is formulated. The cellulose-based polymer is preferably hydroxypropylmethylcellulose.