(19)

(11)

EP 0 910 340 A1

(12)

(43) Date of publication: 28.04.1999 Bulletin 1999/17 (21) Application number: 97914892.0 (22) Date of filing: 05.03.1997

(51) International Patent Classification (IPC):  G01N 27/ 30( . ) A61K 38/ 00( . ) B01D 15/ 08( . ) B01J 20/ 32( . ) C07C 29/ 16( . ) C07C 33/ 18( . ) C07C 57/ 40( . ) C07C 63/ 44( . ) C07C 211/ 57( . ) C07C 317/ 12( . ) C07D 487/ 22( . ) C07F 5/ 00( . ) C07K 1/ 107( . ) C08J 3/ 12( . ) C12N 11/ 02( . ) C12Q 1/ 28( . ) C12Q 1/ 42( . ) G01N 33/ 543( . ) A61K 33/ 44( . ) A61K 39/ 395( . ) B01J 20/ 28( . ) C01B 31/ 02( . ) C07C 29/ 32( . ) C07C 51/ 353( . ) C07C 57/ 72( . ) C07C 209/ 00( . ) C07C 233/ 65( . ) C07C 319/ 14( . ) C07F 1/ 02( . ) C07F 7/ 08( . ) C07K 17/ 08( . ) C09C 1/ 46( . ) C12Q 1/ 26( . ) C12Q 1/ 37( . ) C12Q 1/ 44( . ) (86) International application number: PCT/US1997/003553 (87) International publication number: WO 1997/032571 (12.09.1997 Gazette 1997/39)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 06.03.1996 US 19960037238P (71) Applicant: HYPERION CATALYSIS INTERNATIONAL, INC. Cambridge, MA 02138 (US)

(72) Inventors: FISCHER, Alan Cambridge, MA 02139 (US) HOCH, Robert Hensonville, NY 12439 (US) MOY, David Winchester, MA 01890 (US) LU, Ming Lanham, MD 20706 (US) MARTIN, Mark N. Bethesda, MD 20852 (US) NIU, Chun, Ming Somerville, MA 02144 (US) OGATA, Naoya Sophia University Tokyo (JP) TENNENT, Howard Kennett Square, PA 19348 (US) DONG, Liwen Rockville, MD 20850 (US) SUN, Ji Potomac, MD 20854 (US) HELMS, Larry Germantown, MD 20874 (US) JAMEISON, Fabian Gaithersburg, MD 20879 (US) LIANG, Pam Alhambra, CA 91801 (US) SIMPSON, David N. Bethesda, MD 20852 (US) (74) Representative: Colmer, Stephen Gary, et al  Mathys & Squire 100 Gray's Inn Road London WC1X 8AL London WC1X 8AL (GB)