(19)

(11)

EP 0 910 413 A2

(12)

(43) Date of publication: 28.04.1999 Bulletin 1999/17 (21) Application number: 97921849.0 (22) Date of filing: 02.05.1997

(51) International Patent Classification (IPC):  A61K 9/ 08( . ) A61K 31/ 00( . ) A61K 38/ 17( . ) A61K 47/ 48( . ) A61P 11/ 06( . ) A61K 9/ 12( . ) A61K 38/ 00( . ) A61K 39/ 395( . ) A61P 11/ 00( . ) C07K 14/ 715( . ) (86) International application number: PCT/EP1997/002256 (87) International publication number: WO 1997/041895 (13.11.1997 Gazette 1997/49)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 08.05.1996 US 19960016842P (71) Applicant: F. HOFFMANN-LA ROCHE AG 4070 Basel (CH)	(72) Inventor: RENZETTI, Louis, Martin Verona, NJ 07044 (US) (74) Representative: Braun, Axel  F.Hoffmann-La Roche AG Patent Department (PLP), 124 Grenzacherstrasse 4070 Basel 4070 Basel (CH)