(19)
(11) EP 0 910 634 A2

(12)

(43) Date of publication:
28.04.1999 Bulletin 1999/17

(21) Application number: 97921238.0

(22) Date of filing: 17.04.1997
(51) International Patent Classification (IPC): 
C12N 15/ 09( . )
A61K 31/ 70( . )
C07H 19/ 073( . )
C07H 21/ 04( . )
A61K 38/ 00( . )
A61K 9/ 127( . )
A61K 31/ 7088( . )
C07H 19/ 173( . )
C12N 15/ 113( . )
A61K 48/ 00( . )
(86) International application number:
PCT/US1997/006412
(87) International publication number:
WO 1997/039120 (23.10.1997 Gazette 1997/45)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

(30) Priority: 17.04.1996 US 19960015752P

(71) Applicants:
  • Hoechst Marion Roussel Deutschland GmbH
    65929 Frankfurt am Main (DE)
  • Aronex Pharmaceuticals, Inc.
    The Woodlands, TX 77381 (US)

(72) Inventors:
  • CHAUDHARY, Nilabh
    Louisville, CO 80027 (US)
  • RAO, T., Sudhakar
    The Woodlands, TX 77381 (US)
  • REVANKAR, Ganapathi, R.
    The Woodlands, TX 77381 (US)
  • COSSUM, Paul, A.
    The Woodlands, TX 77381 (US)
  • RANDO, Robert, F.
    The Woodlands, TX 77380 (US)
  • PEYMAN, Anusch
    D-65779 Kelkheim (DE)
  • UHLMANN, Eugen
    D-61479 Glashütten (DE)

(74) Representative: Schwan, Gerhard, Dipl.-Ing. 
Elfenstrasse 32
81739 München
81739 München (DE)

   


(54) ANTISENSE INHIBITORS OF VASCULAR ENDOTHELIAL GROWTH FACTOR (VEgF/VPF) EXPRESSION