(19)

(11)

EP 0 910 641 A1

(12)

(43) Date of publication: 28.04.1999 Bulletin 1999/17 (21) Application number: 98903197.0 (22) Date of filing: 12.02.1998

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61K 31/ 7088( . ) A61K 38/ 00( . ) A61K 48/ 00( . ) A61P 3/ 08( . ) A61P 35/ 00( . ) C07K 14/ 705( . ) C07K 16/ 28( . ) C12N 1/ 19( . ) C12N 5/ 10( . ) C12N 15/ 12( . ) C12Q 1/ 02( . ) G01N 33/ 566( . ) A61K 31/ 70( . ) A61K 35/ 76( . ) A61K 45/ 00( . ) A61P 3/ 04( . ) A61P 3/ 10( . ) C07K 14/ 47( . ) C07K 16/ 18( . ) C12N 1/ 15( . ) C12N 1/ 21( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) C12Q 1/ 68( . ) (86) International application number: PCT/GB1998/000434 (87) International publication number: WO 1998/036062 (20.08.1998 Gazette 1998/33)

(84) Designated Contracting States: BE CH DE DK FR GB IT LI NL (30) Priority: 13.02.1997 GB 19970003011 22.07.1997 EP 19970305485 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford, Middlesex TW8 9EP (GB)	(72) Inventors: TERRETT, Jonathan, Alexander SmithKline Beecham Third Avenue Harlow Essex CM19 5AW (GB) KENWRICK, Susan, Jane The Univ. of Cambridge, P.B. 157, Hill Road, Cambridge CB2 2QQ (GB) WANG, Bo The Univ. of Cambridge, P.B. 157, Hill Road, Cambridge CB2 2QQ (GB) (74) Representative: Crump, Julian Richard John, et al  FJ Cleveland, 40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)