(19)

(11)

EP 0 912 087 A1

(12)

(43) Date of publication: 06.05.1999 Bulletin 1999/18 (21) Application number: 97925474.0 (22) Date of filing: 06.05.1997

(51) International Patent Classification (IPC):  A01N 37/ 02( . ) A01N 37/ 38( . ) A01N 37/ 06( . ) (86) International application number: PCT/US1997/007693 (87) International publication number: WO 1997/041727 (13.11.1997 Gazette 1997/49)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV RO SI (30) Priority: 07.05.1996 EP 19960107169 31.05.1996 US 19960018632P (71) Applicant: AMERICAN CYANAMID COMPANY Madison, New Jersey 07940 (US)	(72) Inventors: DEHNE, Heinz-Wilhelm D-53125 Bonn (DE) BICKERS, Udo D-49835 Wietmarschen (DE) COTTER, Van D-55218 Ingelheim (DE) AVEN, Michael D-55131 Mainz (DE) SIEVERDING, Ewald D-55578 St. Johann (DE) (74) Representative: Wileman, David Francis, Dr., et al  c/o Wyeth Laboratories Huntercombe Lane South Taplow Maidenhead Berkshire SL6 OPH Taplow Maidenhead Berkshire SL6 OPH (GB)