(19)

(11)

EP 0 912 183 A1

(12)

(43) Date of publication: 06.05.1999 Bulletin 1999/18 (21) Application number: 97921314.0 (22) Date of filing: 23.04.1997

(51) International Patent Classification (IPC):  A61K 31/ 00( . ) A61K 31/ 439( . ) A61P 25/ 18( . ) A61P 25/ 28( . ) A61P 27/ 06( . ) C07D 471/ 08( . ) A61K 31/ 435( . ) A61P 25/ 04( . ) A61P 25/ 22( . ) A61P 27/ 00( . ) A61P 43/ 00( . ) (86) International application number: PCT/US1997/006678 (87) International publication number: WO 1997/039753 (30.10.1997 Gazette 1997/46)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 23.04.1996 US 19960016005P (71) Applicant: ELI LILLY AND COMPANY Indianapolis, Indiana 46285 (US)	(72) Inventors: SIMON, Richard, L. Greenwood, IN 46142 (US) WHITESITT, Celia, A. Greenwood, IN 46142 (US) (74) Representative: Hudson, Christopher Mark, et al  Lilly Industries Limited European Patent Operations Erl Wood Manor Windlesham Surrey GU20 6PH Windlesham Surrey GU20 6PH (GB)