SUBSTITUTED OXOBUTYRIC ACIDS AS MATRIX METALLOPROTEASE INHIBITORS - Patent 0912487

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(11)

EP 0 912 487 A1

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(43)	Date of publication:
	06.05.1999 Bulletin 1999/18

(21)	Application number: 97926454.0

(22)	Date of filing: 12.05.1997

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International Patent Classification (IPC):

A61K 31/ 40^{( . )}
A61K 31/ 19^{( . )}
A61K 31/ 4035^{( . )}
A61P 1/ 02^{( . )}
A61P 7/ 02^{( . )}
A61P 13/ 02^{( . )}
A61P 19/ 00^{( . )}
A61P 21/ 00^{( . )}
A61P 27/ 02^{( . )}
A61P 35/ 00^{( . )}
A61P 43/ 00^{( . )}
C07D 209/ 48^{( . )}

A61K 31/ 00^{( . )}
A61K 31/ 403^{( . )}
A61P 1/ 00^{( . )}
A61P 7/ 00^{( . )}
A61P 13/ 00^{( . )}
A61P 15/ 00^{( . )}
A61P 19/ 02^{( . )}
A61P 27/ 00^{( . )}
A61P 29/ 00^{( . )}
A61P 35/ 04^{( . )}
C07C 59/ 90^{( . )}
C07D 253/ 08^{( . )}

(86)	International application number:
	PCT/US1997/007975

(87)	International publication number:
	WO 1997/043238 (20.11.1997 Gazette 1997/50)

(84)	Designated Contracting States:
	AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

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Priority:

15.05.1996 US 19960648384

(71)	Applicant: Bayer Corporation
	Pittsburgh, PA 15205-9741 (US)

(72)	Inventors:
	DIXON, Brian, R. Woodbridge, CT 06525 (US) CHEN, Jinshan Hamden, CT 06518 (US) VAN ZANDT, Michael Guilford, CT 06437 (US) BRITTELLI, David, R. Branford, CT 06405 (US)

(74)	Representative: Burkert, Frank, et al
	Bayer AG, Konzernbereich RP Patente und Lizenzen 51368 Leverkusen 51368 Leverkusen (DE)

(54)	SUBSTITUTED OXOBUTYRIC ACIDS AS MATRIX METALLOPROTEASE INHIBITORS