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(11)

EP 0 912 746 A2

(12)

(43) Date of publication: 06.05.1999 Bulletin 1999/18 (21) Application number: 97931547.0 (22) Date of filing: 10.07.1997

(51) International Patent Classification (IPC):  G01N 33/ 573( . ) C12N 9/ 64( . ) C12N 15/ 57( . ) C12R 1/ 91( . ) C12N 9/ 50( . ) C12N 15/ 09( . ) C12Q 1/ 68( . ) (86) International application number: PCT/US1997/011637 (87) International publication number: WO 1998/002557 (22.01.1998 Gazette 1998/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: LT LV RO (30) Priority: 12.07.1996 US 19960678916 (71) Applicant: SCHERING CORPORATION Kenilworth, New Jersey 07033-0530 (US)	(72) Inventors: DALIE, Barbara Annandale, NJ 08801 (US) FAN, Xuedong Basking Ridge, NJ 07920 (US) LUNDELL, Daniel Flemington, NJ 08822 (US) LUNN, Charles, A. Somerville, NJ 08876 (US) TAN, Jimmy, C. Edison, NJ 08820 (US) ZAVODNY, Paul, J. Mountainside, NJ 07092 (US) (74) Representative: Ritter, Stephen David, et al  Mathys & Squire 100 Grays Inn Road London WC1X 8AL London WC1X 8AL (GB)