(19)

(11)

EP 0 914 143 A1

(12)

(43) Date of publication: 12.05.1999 Bulletin 1999/19 (21) Application number: 97930662.0 (22) Date of filing: 07.07.1997

(51) International Patent Classification (IPC):  A61K 9/ 00( . ) A61K 38/ 00( . ) A61K 47/ 32( . ) A61K 9/ 12( . ) A61K 38/ 13( . ) (86) International application number: PCT/GB1997/001851 (87) International publication number: WO 1998/001147 (15.01.1998 Gazette 1998/02)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 08.07.1996 GB 19960014326 02.08.1996 US 19960023048P (71) Applicant: RHONE-POULENC RORER LIMITED West Malling, Kent ME19 4TA (GB)	(72) Inventor: BELL, Alexander, Rhone-Poulenc Rorer Limited Holmes Chapel, Cheshire CW4 8BE (GB) (74) Representative: Caffin, Lee  Rhône-Poulenc Rorer Limited, Rainham Road South Dagenham, Essex RM10 7XS Dagenham, Essex RM10 7XS (GB)