(19)

(11)

EP 0 914 338 A2

(12)

(43) Date of publication: 12.05.1999 Bulletin 1999/19 (21) Application number: 97927946.0 (22) Date of filing: 29.05.1997

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C07K 14/ 47( . ) C12N 15/ 12( . ) A61K 38/ 00( . ) C12N 15/ 113( . ) (86) International application number: PCT/US1997/009584 (87) International publication number: WO 1997/045542 (04.12.1997 Gazette 1997/52)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 29.05.1996 US 19960018557P (71) Applicant: GENZYME CORPORATION Framingham, Massachusetts 01701 (US)	(72) Inventors: BEAUDRY, Gary, A. Upper Montclair, NJ 07043 (US) BERTELSEN, Arthur, H. Ridgewood, NJ 07450 (US) GALELLA, Elizabeth, A. Washington Township, NJ 07645 (US) MADDEN, Stephen, I. Cranbury, NJ 08512 (US) (74) Representative: Dean, John Paul, et al  Withers & Rogers, Goldings House, 2 Hays Lane London SE1 2HW London SE1 2HW (GB)