(19)

(11)

EP 0 914 436 A1

(12)

(43) Date of publication: 12.05.1999 Bulletin 1999/19 (21) Application number: 97928187.0 (22) Date of filing: 12.06.1997

(51) International Patent Classification (IPC):  C07K 14/ 415( . ) C12N 15/ 82( . ) C12N 15/ 29( . ) (86) International application number: PCT/EP1997/003070 (87) International publication number: WO 1997/047745 (18.12.1997 Gazette 1998/02)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 13.06.1996 WO 1996ES00130 (71) Applicant: CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS 28006 Madrid (ES)

(72) Inventors: GUTIERREZ-ARMENTA, C.-Centro de Biologia Molecul. E-28049 Cantoblanco (ES) XIE, Qi;-Centro de Biologia Molecular E-28049 Cantoblanco (ES) PELAYO SANZ-BURGOS, A.-Centro de Biologia Molecul E-28049 Cantoblanco (ES) SUAREZ LOPEZ, Paula-Centro de Biologia Molecular E-28049 Cantoblanco (ES) (74) Representative: Dolan, Anthony Patrick, et al  BTG International Ltd., 10 Fleet Place, Limeburner Lane London EC4M 7SB London EC4M 7SB (GB)