(19)

(11)

EP 0 915 653 A1

(12)

(43) Date of publication: 19.05.1999 Bulletin 1999/20 (21) Application number: 97932256.0 (22) Date of filing: 24.06.1997

(51) International Patent Classification (IPC):  A61P 25/ 04( . ) C07D 235/ 06( . ) C07D 223/ 16( . ) C07D 333/ 54( . ) (86) International application number: PCT/US1997/010905 (87) International publication number: WO 1997/049287 (31.12.1997 Gazette 1998/05)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 27.06.1996 US 19960020657P (71) Applicant: SMITHKLINE BEECHAM CORPORATION Philadelphia Pennsylvania 19103 (US)	(72) Inventor: WIDDOWSON, Katherine, L. King of Prussia, PA 19406 (US) (74) Representative: Blakey, Alison Jane, et al  Smithkline Beecham, Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex, TW8 9EP Brentford, Middlesex, TW8 9EP (GB)