(19)

(11)

EP 0 915 969 A1

(12)

(43) Date of publication: 19.05.1999 Bulletin 1999/20 (21) Application number: 97917856.0 (22) Date of filing: 02.04.1997

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 38/ 00( . ) A61K 39/ 395( . ) A61K 47/ 48( . ) A61P 31/ 18( . ) C07K 14/ 47( . ) C07K 16/ 00( . ) C12N 5/ 06( . ) A61K 31/ 00( . ) A61K 38/ 19( . ) A61K 45/ 00( . ) A61P 31/ 00( . ) C07K 7/ 00( . ) C07K 14/ 715( . ) C07K 16/ 28( . ) (86) International application number: PCT/US1997/005597 (87) International publication number: WO 1997/037005 (09.10.1997 Gazette 1997/43)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 02.04.1996 US 19960627684 14.06.1996 US 19960663616 25.06.1996 US 19960673682 (71) Applicant: PROGENICS PHARMACEUTICALS, INC. Tarrytown, NY 10591 (US)	(72) Inventors: ALLAWAY, Graham, P. Westminster, MD 21157-6231 (US) LITWIN, Virginia, M. Syracuse, NY 13206 (US) MADDON, Paul, J. New York, NY 10032 (US) OLSON, William, C. Tarrytown, NY 10591 (US) (74) Representative: VOSSIUS & PARTNER  Postfach 86 07 67 81634 München 81634 München (DE)