(19)

(11)

EP 0 915 971 A2

(12)

(43) Date of publication: 19.05.1999 Bulletin 1999/20 (21) Application number: 97932156.0 (22) Date of filing: 06.06.1997

(51) International Patent Classification (IPC):  A23K 1/ 16( . ) A61K 38/ 00( . ) A61K 45/ 00( . ) A61P 7/ 04( . ) A61P 7/ 08( . ) A61P 37/ 02( . ) C07K 14/ 47( . ) C12N 1/ 15( . ) C12N 1/ 21( . ) C12N 15/ 09( . ) C12P 21/ 02( . ) A61K 35/ 12( . ) A61K 39/ 00( . ) A61K 48/ 00( . ) A61P 7/ 06( . ) A61P 35/ 00( . ) A61P 43/ 00( . ) C07K 14/ 52( . ) C12N 1/ 19( . ) C12N 5/ 10( . ) C12N 15/ 12( . ) (86) International application number: PCT/US1997/009865 (87) International publication number: WO 1997/046682 (11.12.1997 Gazette 1998/01)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 07.06.1996 US 19960659224 02.06.1997 US 19970867677 (71) Applicant: GENETICS INSTITUTE, INC. Cambridge, Massachusetts 02140 (US)

(72) Inventors: JACOBS, Kenneth Newton, MA 02160 (US) MCCOY, John, M. Reading, MA 01867 (US) RACIE, Lisa, A. Acton, MA 01720 (US) LAVALLIE, Edward, R. Tewksbury, MA 01876 (US) MERBERG, David Acton, MA 01720 (US) TREACY, Maurice Chestnut Hill, MA 02167 (US) EVANS, Cheryl Brookline, MA 02146 (US) BOWMAN, Michael Canton, MA 02021 (US) SPAULDING, Vikki Billerica, MA 01821 (US) (74) Representative: Frohwitter, Bernhard, Dipl.-Ing.  Patent- und Rechtsanwälte, Possartstrasse 20 81679 München 81679 München (DE)