(19)

(11)

EP 0 915 977 A1

(12)

(43) Date of publication: 19.05.1999 Bulletin 1999/20 (21) Application number: 96915650.0 (22) Date of filing: 08.05.1996

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) A61K 38/ 00( . ) C07K 14/ 20( . ) C07K 19/ 00( . ) C12N 15/ 31( . ) G01N 33/ 53( . ) A61K 39/ 00( . ) A61K 31/ 00( . ) A61P 33/ 00( . ) C07K 16/ 12( . ) C12N 15/ 00( . ) C12P 21/ 02( . ) G01N 33/ 569( . ) C12R 1/ 01( . ) (86) International application number: PCT/US1996/006610 (87) International publication number: WO 1997/042325 (13.11.1997 Gazette 1997/49)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (71) Applicant: YALE UNIVERSITY New Haven CT 06520 (US)	(72) Inventors: FIKRIG, Erol Guilford, CT 06437 (US) SUK, Kyoungho Taegu 703-031 (KR) BARTHOLD, Stephen, W. Madison, CT 06443 (US) FLAVELL, Richard, A. Guilford, CT 06437 (US) (74) Representative: VOSSIUS & PARTNER  Siebertstrasse 4 81675 München 81675 München (DE)