(19)

(11)

EP 0 917 584 A1

(12)

(43) Date of publication: 26.05.1999 Bulletin 1999/21 (21) Application number: 97938044.0 (22) Date of filing: 25.07.1997

(51) International Patent Classification (IPC):  A01H 5/ 00( . ) C07K 14/ 195( . ) C12N 15/ 09( . ) C12N 15/ 82( . ) C07K 14/ 01( . ) C12N 5/ 10( . ) C12N 15/ 34( . ) C12P 21/ 02( . ) (86) International application number: PCT/US1997/013094 (87) International publication number: WO 1998/004724 (05.02.1998 Gazette 1998/05)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 26.07.1996 US 19960022680P (71) Applicant: THE UNIVERSITY OF FLORIDA Gainesville, Florida 32611 (US)	(72) Inventors: POLSTON, Jane, E. Bradenton, FL 34203 (US) HIEBERT, Ernest Gainesville, FL 32605 (US) ABOUZID, Ahmed Gainesville, FL 32607 (US) (74) Representative: Perry, Robert Edward  GILL JENNINGS & EVERY Broadgate House 7 Eldon Street London EC2M 7LH London EC2M 7LH (GB)