(19)

(11)

EP 0 918 855 A1

(12)

(43) Date of publication: 02.06.1999 Bulletin 1999/22 (21) Application number: 97927729.0 (22) Date of filing: 22.05.1997

(51) International Patent Classification (IPC):  A01K 67/ 027( . ) A61P 13/ 12( . ) C07K 16/ 18( . ) C12N 1/ 19( . ) C12N 5/ 10( . ) C12N 15/ 12( . ) C12Q 1/ 68( . ) A61K 38/ 00( . ) C07K 14/ 47( . ) C12N 1/ 15( . ) C12N 1/ 21( . ) C12N 15/ 09( . ) C12P 21/ 08( . ) G01N 33/ 68( . ) (86) International application number: PCT/US1997/008799 (87) International publication number: WO 1997/044457 (27.11.1997 Gazette 1997/51)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 24.05.1996 US 19960655360 03.06.1996 US 19960658136 (71) Applicants: GENZYME CORPORATION Framingham, Massachusetts 01701 (US) THE JOHNS HOPKINS UNIVERSITY Baltimore, Maryland 21205 (US)	(72) Inventors: KLINGER, Katherine Sudbury, MA 01776 (US) BURN, Timothy Northborough, MA 01532 (US) CONNORS, Timothy Hopkinton, MA 01748 (US) DACKOWSKI, William Hopkinton, MA 01748 (US) GERMINO, Gregory Baltimore, MD 21210 (US) QIAN, Feng Baltimore, MD 21218 (US) (74) Representative: Roberts, Alison Christine, et al  Kilburn & Strode, 20 Red Lion Street London WC1R 4PJ London WC1R 4PJ (GB)