(19)

(11)

EP 0 918 857 A1

(12)

(43) Date of publication: 02.06.1999 Bulletin 1999/22 (21) Application number: 97938330.0 (22) Date of filing: 14.08.1997

(51) International Patent Classification (IPC):  G01N 33/ 53( . ) A61K 35/ 12( . ) A61K 48/ 00( . ) A61P 15/ 00( . ) A61P 25/ 00( . ) C07K 14/ 47( . ) C12N 1/ 15( . ) C12N 1/ 21( . ) C12N 15/ 09( . ) C12Q 1/ 68( . ) A61K 31/ 7088( . ) A61K 38/ 00( . ) A61P 1/ 00( . ) A61P 17/ 00( . ) A61P 35/ 00( . ) C07K 16/ 18( . ) C12N 1/ 19( . ) C12N 5/ 10( . ) C12N 15/ 12( . ) G01N 33/ 574( . ) (86) International application number: PCT/US1997/014378 (87) International publication number: WO 1998/006846 (19.02.1998 Gazette 1998/07)

(84) Designated Contracting States: BE DE ES FR GB IT NL (30) Priority: 16.08.1996 US 19960689974 (71) Applicant: INCYTE PHARMACEUTICALS, INC. Palo Alto, CA 94304 (US)	(72) Inventors: AU-YOUNG, Janice Berkeley, CA 94702 (US) HAWKINS, Phillip, R. Mountain View, CA 94034 (US) (74) Representative: Wright, Simon Mark  J.A. Kemp & Co. 14 South Square Gray's Inn London WC1R 5LX London WC1R 5LX (GB)