(19)
(11) EP 0 918 860 A2

(12)

(43) Date of publication:
02.06.1999 Bulletin 1999/22

(21) Application number: 97929846.0

(22) Date of filing: 06.06.1997
(51) International Patent Classification (IPC): 
A01K 67/ 027( . )
A61K 45/ 00( . )
A61P 19/ 00( . )
C07K 14/ 525( . )
C07K 16/ 24( . )
C12N 15/ 09( . )
C12N 15/ 85( . )
G01N 33/ 15( . )
G01N 33/ 53( . )
G01N 33/ 577( . )
A61K 38/ 00( . )
A61P 7/ 00( . )
A61P 29/ 00( . )
C07K 14/ 705( . )
C12N 1/ 21( . )
C12N 15/ 19( . )
C12P 21/ 08( . )
G01N 33/ 50( . )
G01N 33/ 566( . )
A61K 48/ 00( . )
(86) International application number:
PCT/US1997/009895
(87) International publication number:
WO 1997/046686 (11.12.1997 Gazette 1998/01)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE
Designated Extension States:
AL LT LV RO SI

(30) Priority: 07.06.1996 US 19960660562

(71) Applicant: AMGEN INC.
Thousand Oaks, CA 91320-1789 (US)

(72) Inventors:
  • JOHNSON, Merrie, J.
    Thousand Oaks, CA 91362 (US)
  • SIMONET, William, S.
    Newbury Park, CA 91320 (US)
  • DANILENKO, Dimitry, M.
    Camarillo, CA 93012 (US)

(74) Representative: Grünecker, Kinkeldey, Stockmair & Schwanhäusser Anwaltssozietät 
Maximilianstrasse 58
80538 München
80538 München (DE)

   


(54) TUMOR NECROSIS FACTOR-RELATED POLYPEPTIDE