(19)

(11)

EP 0 920 253 A1

(12)

(43) Date of publication: 09.06.1999 Bulletin 1999/23 (21) Application number: 97939515.0 (22) Date of filing: 15.08.1997

(51) International Patent Classification (IPC):  A61P 1/ 04( . ) A61P 7/ 02( . ) A61P 9/ 10( . ) A61P 11/ 06( . ) A61P 17/ 00( . ) A61P 19/ 02( . ) A61P 37/ 06( . ) C07C 279/ 22( . ) C07C 279/ 28( . ) A61K 31/ 155( . ) A61P 9/ 02( . ) A61P 11/ 00( . ) A61P 13/ 12( . ) A61P 17/ 06( . ) A61P 25/ 28( . ) C07C 279/ 18( . ) C07C 279/ 24( . ) C07C 335/ 16( . ) (86) International application number: PCT/US1997/014825 (87) International publication number: WO 1998/006262 (19.02.1998 Gazette 1998/07)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 15.08.1996 US 19960023991P (71) Applicant: SMITHKLINE BEECHAM CORPORATION Philadelphia, PA 19102 (US)	(72) Inventors: BRYAN, Deborah, Lynn West Chester, PA 19380 (US) GLEASON, John, Gerald Downington, PA 19335 (US) WIDDOWSON, Katherine, L. King of Prussia, PA 19406 (US) (74) Representative: Blakey, Alison Jane, et al  Smithkline Beecham, Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex, TW8 9EP Brentford, Middlesex, TW8 9EP (GB)