(19)
(11) EP 0 920 328 A1

(12)

(43) Date of publication:
09.06.1999 Bulletin 1999/23

(21) Application number: 97938530.0

(22) Date of filing: 22.08.1997
(51) International Patent Classification (IPC): 
C12N 15/ 09( . )
A61K 47/ 48( . )
C07K 14/ 705( . )
C12N 15/ 12( . )
A61K 38/ 00( . )
A61P 35/ 00( . )
C07K 14/ 74( . )
(86) International application number:
PCT/US1997/014814
(87) International publication number:
WO 1998/007441 (26.02.1998 Gazette 1998/08)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE

(30) Priority: 23.08.1996 US 19960023437P

(71) Applicants:
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Cambridge, MA 02139 (US)
  • The Board of Trustees for the University of Illinois
    Urbana, Illinois 61801 (US)

(72) Inventors:
  • EISEN, Herman, N.
    Waban, MA 02168 (US)
  • KRANZ, David, M.
    Champaign, IL 61821 (US)

(74) Representative: Jump, Timothy John Simon, et al 
Venner Shipley & Co. 20 Little Britain
London EC1A 7DH
London EC1A 7DH (GB)

   


(54) ALLOGENEIC HISTOCOMPATIBILITY COMPLEXES AS MEDIATORS OF CELL DESTRUCTION