(19)

(11)

EP 0 921 798 A1

(12)

(43) Date of publication: 16.06.1999 Bulletin 1999/24 (21) Application number: 97931945.0 (22) Date of filing: 14.07.1997

(51) International Patent Classification (IPC):  C07D 277/ 20( . ) A61K 31/ 425( . ) A61K 31/ 427( . ) A61K 45/ 00( . ) A61P 3/ 06( . ) A61P 5/ 50( . ) C07D 277/ 34( . ) C07D 417/ 12( . ) A61K 31/ 00( . ) A61K 31/ 426( . ) A61K 31/ 4439( . ) A61P 3/ 04( . ) A61P 3/ 10( . ) A61P 9/ 00( . ) C07D 417/ 06( . ) (86) International application number: PCT/GB1997/001928 (87) International publication number: WO 1998/002159 (22.01.1998 Gazette 1998/03)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: SI (30) Priority: 12.07.1996 GB 19960014751 12.07.1996 GB 19960014740 05.08.1996 GB 19960016412 05.08.1996 GB 19960016409 05.08.1996 GB 19960016407 (71) Applicant: SMITHKLINE BEECHAM PLC Brentford, Middlesex TW8 9EP (GB)	(72) Inventors: POSTE, George Henry, SmithKline Beecham Pharm. Harlow Essex CM19 5AW (GB) Smith, Stephen Alistair, SmithKline Beecham Pharm. Harlow Essex CM19 5AW (GB) (74) Representative: Rutter, Keith, Dr., et al  SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)