(19)

(11)

EP 0 922 042 A1

(12)

(43) Date of publication: 16.06.1999 Bulletin 1999/24 (21) Application number: 97936440.0 (22) Date of filing: 07.08.1997

(51) International Patent Classification (IPC):  A61K 31/ 496( . ) A61P 29/ 00( . ) C07D 209/ 08( . ) C07D 401/ 12( . ) A61K 31/ 506( . ) A61P 43/ 00( . ) C07D 209/ 42( . ) C07D 403/ 12( . ) (86) International application number: PCT/US1997/013873 (87) International publication number: WO 1998/006715 (19.02.1998 Gazette 1998/07)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: SI (30) Priority: 09.08.1996 US 19960023638P (71) Applicants: SMITHKLINE BEECHAM CORPORATION Philadelphia Pennsylvania 19103 (US) SMITHKLINE BEECHAM PLC Brentford, Middlesex TW8 9EP (GB)	(72) Inventors: ADAMS, Jerry, Leroy Wayne, PA 19087 (US) BOEHM, Jeffrey, Charles King of Prussia, PA 19406 (US) CHAN, George, Wai-Kin Wynnewood, PA 19096 (US) RAHMAN, Shirley, K. Hertfordshire (GB) (74) Representative: Connell, Anthony Christopher, et al  SmithKline Beecham plc Corporate Intellectual Property, Two New Horizons Court Brentford, Middlesex TW8 9EP Brentford, Middlesex TW8 9EP (GB)