(19)

(11)

EP 0 922 222 A1

(12)

(43) Date of publication: 16.06.1999 Bulletin 1999/24 (21) Application number: 97905574.0 (22) Date of filing: 31.01.1997

(51) International Patent Classification (IPC):  G01N 33/ 573( . ) G01N 33/ 15( . ) C12Q 1/ 34( . ) G01N 33/ 574( . ) (86) International application number: PCT/US1997/000546 (87) International publication number: WO 1997/028446 (07.08.1997 Gazette 1997/34)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 01.02.1996 US 19960010976P (71) Applicant: THE UNIVERSITY OF MIAMI Miami, Florida 33101 (US)	(72) Inventors: LOKESHWAR, Vinata, B. Miami, FL 33176 (US) BLOCK, Norman, L. Miami, FL 33156 (US) PHAM, Henri, T. Houston, TX 77081 (US) (74) Representative: Smart, Peter John  W.H. BECK, GREENER & CO 7 Stone Buildings Lincoln's Inn London WC2A 3SZ London WC2A 3SZ (GB)