(19)

(11)

EP 0 922 295 A1

(12)

(43) Date of publication: 16.06.1999 Bulletin 1999/24 (21) Application number: 97937712.0 (22) Date of filing: 26.08.1997

(51) International Patent Classification (IPC):  C12M 1/ 34( . ) C12Q 1/ 00( . ) H01J 49/ 00( . ) C12N 1/ 00( . ) C12Q 1/ 04( . ) H01J 49/ 04( . ) (86) International application number: PCT/GB1997/002278 (87) International publication number: WO 1998/009314 (05.03.1998 Gazette 1998/09)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE Designated Extension States: AL LT LV RO SI (30) Priority: 27.08.1996 GB 19960017852 (71) Applicant: THE MANCHESTER METROPOLITAN UNIVERSITY Manchester M15 6BH (GB)	(72) Inventors: CLAYDON, Martin Arthur Didsbury, Manchester M20 2TU (GB) DAVEY, Simon Nicholas Accrington, Lancs. BB5 0BE (GB) EDWARDS JONES, Valerie Rochdale, Lancs. QL12 7SX (GB) GORDON, Derek Boyd Bury, Lancs. BL0 9YY (GB) (74) Representative: Evans, David Charles, et al  40-43 Chancery Lane London WC2A 1JQ London WC2A 1JQ (GB)