(19)

(11)

EP 0 923 561 A1

(12)

(43) Date of publication: 23.06.1999 Bulletin 1999/25 (21) Application number: 97939443.0 (22) Date of filing: 22.08.1997

(51) International Patent Classification (IPC):  A61K 31/ 505( . ) A61K 31/ 554( . ) A61P 11/ 06( . ) A61P 19/ 00( . ) A61P 27/ 02( . ) C07D 239/ 06( . ) C07D 281/ 06( . ) C07D 409/ 12( . ) C07D 413/ 12( . ) C07D 487/ 06( . ) A61K 31/ 551( . ) A61P 1/ 02( . ) A61P 17/ 00( . ) A61P 19/ 02( . ) A61P 43/ 00( . ) C07D 243/ 08( . ) C07D 403/ 12( . ) C07D 409/ 14( . ) C07D 413/ 14( . ) (86) International application number: PCT/US1997/014553 (87) International publication number: WO 1998/008823 (05.03.1998 Gazette 1998/09)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE (30) Priority: 28.08.1996 US 19960024846P (71) Applicant: THE PROCTER & GAMBLE COMPANY Cincinnati, Ohio 45202 (US)

(72) Inventors: PIKUL, Stanislaw Mason, OH 45040 (US) MCDOW-DUNHAM, Kelly, Lynn Loveland, OH 45140 (US) DE, Biswanath Cincinnati, OH 45241 (US) TAIWO, Yetunde, Olabisi West Chester, OH 45069 (US) ALMSTEAD, Neil, Gregory Loveland, OH 45140 (US) BRADLEY, Rimma, Sandler Fairfield, OH 45014 (US) NATCHUS, Michael, George Glendale, OH 45246 (US) CUPPS, Thomas, Lee Oxford, OH 45046 (US) (74) Representative: Woof, Victoria, et al  Procter & Gamble Technical Centers Limited, Lovett House, Lovett Road Staines, Middlesex TW18 3AZ Staines, Middlesex TW18 3AZ (GB)