NOVEL BENZOFURAN-4-CARBOXAMIDES

Description

Field of application of the invention

[0001] The invention relates to novel benzofuran-4-carboxamides which are used in the pharmaceutical industry for the production of medicaments.

Known technical background

[0002] International Patent Application WO92/12961 describes benzamides having PDE-inhibiting properties. - International Patent Application WO93/25517 discloses trisubstituted phenyl derivatives as selective PDE IV inhibitors. - International Patent Application WO94/02465 describes inhibitors of c-AMP phosphodiesterase and of TNF. - International Patent Application WO95/01338 describes fluoroalkoxy-substituted benzamides and their use as cyclic nucleotide phosphodiesterase inhibitors. - International Patent Application WO96/03399 discloses dihydrobenzofuran carboxamides as selective PDEIV inhibitors. - International Patent Application WO97/20833 discloses benzofuran carboxamides and sulphonamides as inhibitors of phosphodiesterase IV.

Description of the invention

[0003] It has now been found that the novel benzofuran-4-carboxamides described in greater detail below have surprising and particularly advantageous properties.

[0004] The invention thus relates to compounds of the formula I (see attached formula sheet), in which

R1

is 1-2C-alkoxy or 1-2C-alkoxy which is completely or mainly substituted by fluorine,

R2

is 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl,

Ar

is phenyl, pyridyl, phenyl which is substituted by R3, R4 and R5 or pyridyl which is substituted by R6, R7, R8 and R9, where
R3  is hydroxyl, halogen, cyano, carboxyl, trifluoromethyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyl, 1-4C-alkylcarbonyloxy, amino, mono- or di-1-4C-alkylamino or 1-4C-alkylcarbonylamino,
R4  is hydrogen, hydroxyl, halogen, amino, trifluoromethyl, 1-4C-alkyl or 1-4C-alkoxy,
R5  is hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy,
R6  is hydroxyl, halogen, cyano, carboxyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl or amino,
R7  is hydrogen, halogen, amino or 1-4C-alkyl,
R8  is hydrogen or halogen and
R9  is hydrogen or halogen,

the salts of these compounds, and the N-oxides of the pyridines and their salts with the proviso that the compound 2-Butyl-4-(3,5-dichloropyridin-4-ylaminocarbonyl)-7-methoxy-benzofuran or pharmaceutically acceptable salts thereof are excluded.

[0005] In particular the invention relates to compounds of the formula I, in which

R1

is 1-2C-alkoxy or 1-2C-alkoxy which is completely or mainly substituted by fluorine,

R2

is 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl,

Ar

is phenyl, pyridyl, phenyl which is substituted by R3, R4 and R5 or pyridyl which is substituted by R6, R7, R8 and R9, where
R3  is hydroxyl, halogen, cyano, carboxyl, trifluoromethyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyl, 1-4C-alkylcarbonyloxy, amino, mono- or di-1-4C-alkylamino or 1-4C-alkylcarbonylamino,
R4  is hydrogen, hydroxyl, halogen, amino, trifluoromethyl, 1-4C-alkyl or 1-4C-alkoxy,
R5  is hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy,
R6  is hydroxyl, halogen, cyano, carboxyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl or amino,
R7  is hydrogen, halogen, amino or 1-4C-alkyl,
R8  is hydrogen or halogen and
R9  is hydrogen or halogen,

and where R2 is not ethyl or 2,2-dimethylpropyl when R1 is methoxy,
the salts of these compounds, and the N-oxides of the pyridines and their salts with the proviso that the compound 2-Butyl-4-(3,5-dichloropyridin-4-ylaminocarbonyl)-7-methoxy-benzofuran or pharmaceutically acceptable salts thereof are excluded.

[0006] 1-2C-Alkoxy is a radical which, beside the oxygen atom, contains an ethyl radical or preferably a methyl radical.

[0007] 1-2C-Alkoxy which is completely or mainly substituted by fluorine is, for example, the 1,2,2-trifluoroethoxy, the perfluoroethoxy and in particular the 1,1,2,2-tetrafluoroethoxy, the trifluoromethoxy, the 2,2,2-trifluoroethoxy and preferably the difluoromethoxy radical.

[0008] 1-7C-Alkyl is straight-chain or branched alkyl radicals having 1 to 7 carbon atoms. Examples are the heptyl, isoheptyl (2-methylhexyl), hexyl, isohexyl (2-methylpentyl), neohexyl (2,2-dimethylbutyl), pentyl, isopentyl (3-methylbutyl), neopentyl (2,2-dimethylpropyl), butyl, isobutyl, sec-butyl, tert-butyl, propyl, isopropyl, ethyl and the methyl radical.

[0009] 3-7C-Cycloalkyl is the cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl and cycloheptyl radical. The 3-5C-cycloalkyl radicals cyclopropyl, cyclobutyl and cyclopentyl are preferred.

[0010] 3-7C-Cycloalkylmethyl is a methyl radical which is substituted by one of the abovementioned 3-7C-cycloalkyl radicals. The 3-5C-cycloalkylmethyl radicals cyclopropylmethyl, cyclobutylmethyl and cyclopentylmethyl are preferred.

[0011] Halogen within the meaning of the present invention is bromine, chlorine and fluorine.

[0012] 1-4C-Alkyl is straight-chain or branched alkyl radicals having 1 to 4 carbon atoms. Examples are the butyl, isobutyl, sec-butyl, tert-butyl, propyl, isopropyl, ethyl and the methyl radical.

[0013] 1-4C-Alkoxy is a radical which, beside the oxygen atom, contains one of the abovementioned 1-4C-alkyl radicals. Examples are the methoxy and the ethoxy radicals.

[0014] 1-4C-Alkoxycarbonyl is a carbonyl group to which one of the abovementioned 1-4C-alkoxy radicals is bonded. Examples are the methoxycarbonyl (CH₃O-CO-) and the ethoxycarbonyl radical (CH₃CH₂O-CO-).

[0015] 1-4C-Alkylcarbonyl is a carbonyl group to which one of the abovementioned 1-4C-alkyl radicals is bonded. An example is the acetyl radical (CH₃CO-).

[0016] 1-4C-Alkylcarbonyloxy radicals, beside the oxygen atom, contain one of the abovementioned 1-4C-alkylcarbonyl radicals. An example is the acetoxy radical (CH₃CO-O-).

[0017] Examples of mono- or di-1-4C-alkylamino radicals are the methylamino, the dimethylamino and the diethylamino radical.

[0018] An example of a 1-4C-alkylcarbonylamino radical is the acetylamido radical (-NH-CO-CH₃).

[0019] The substituents R3, R4 and R5 can be linked to the phenyl radical in any desired position and combination. Exemplary phenyl radicals substituted by R3, R4 and R5 are the radicals 2-acetylphenyl, 2-aminophenyl, 2-bromophenyl, 2-chlorophenyl, 2,3-dichlorophenyl, 2,4-dichlorophenyl, 4-diethylamino-2-methylphenyl, 4-bromo-2-trifluoromethylphenyl, 2-carboxy-5-chlorophenyl, 3,5-dichloro-2-hydroxyphenyl, 2-bromo-4-carboxy-5-hydroxyphenyl, 2,6-dichlorophenyl, 2,5-dichlorophenyl, 2,4,6-trichlorophenyl, 2,4,6-trifluorophenyl, 2,6-dibromophenyl, 2-cyanophenyl, 4-cyano-2-fluorophenyl, 2-fluorophenyl, 2,4-difluorophenyl, 2,6-difluorophenyl, 2-chloro-6-fluorophenyl, 2-hydroxyphenyl, 2-hydroxy-4-methoxyphenyl, 2,4-dihydroxyphenyl, 2-methoxyphenyl, 2,3-dimethoxyphenyl, 2,4-dimethoxyphenyl, 2,6-dimethoxyphenyl, 2-dimethylaminophenyl, 2-methylphenyl, 2-chloro-6-methylphenyl, 2,4-dimethylphenyl, 2,6-dimethylphenyl, 2,3-dimethylphenyl, 2-methoxycarbonylphenyl, 2-trifluoromethylphenyl, 2,6-dichloro-4-methoxyphenyl, 2,6-dichloro-4-cyanophenyl, 2,6-dichloro-4-aminophenyl, 2,6-dichloro-4-methoxycarbonylphenyl, 4-acetylamino-2,6-dichlorophenyl, 2,6-dichloro-4-ethoxycarbonylphenyl, 4-carboxyphenyl and 4-carboxy-2,6-dichlorophenyl.

[0020] The substituents R6, R7, R8 and R9 can be linked to the pyridyl ring in any desired position and combination. Exemplary pyridyl radicals substituted by R6, R7, R8 and R9 are the radicals 3,5-dichloropyrid-4-yl, 2,6-diaminopyrid-3-yl, 4-aminopyrid-3-yl, 3-methylpyrid-2-yl, 4-methylpyrid-2-yl, 5-hydroxypyrid-2-yl, 4-chloropyrid-3-yl, 3-chloropyrid-2-yl, 3-chloropyrid-4-yl, 2-chloropyrid-3-yl, 2,3,5,6-tetrafluoropyrid-4-yl, 3,5-dichloro-2,6-difluoropyrid-4-yl, 3,5-dibromo-pyrid-2-yl, 3,5-dibromopyrid-4-yl, 3,5-dichloropyrid-4-yl, 2,6-dichloropyrid-3-yl, 3,5-dimethylpyrid-4-yl, 3-chloro-2,5,6-trifluoropyrid-4-yl and 2,3,5-trifluoropyrid-4-yl.

[0021] Compounds of the formula I to be emphasized are those in which

R1

is 1-2C-alkoxy or 1-2C-alkoxy which is completely or mainly substituted by fluorine,

R2

is 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl,

Ar

is phenyl, pyridyl, phenyl substituted by R3, R4 and R5 or pyridyl substituted by R6, R7, R8 and R9, where
R3  is halogen, carboxyl or 1-4C-alkoxycarbonyl,
R4  is hydrogen or halogen,
R5  is hydrogen or halogen,
R6  is halogen,
R7  is hydrogen or halogen, and
R8 and R9  are hydrogen,

the salts of these compounds, and the N-oxides of the pyridines and their salts with the proviso that the compound 2-Butyl-4-(3,5-dichloropyridin-4-ylaminocarbonyl)-7-methoxy-benzofuran or pharmaceutically acceptable salts thereof are excluded.

[0022] Preferred compounds of the formula I to be emphasized are those in which

R1

is 1-2C-alkoxy or 1-2C-alkoxy which is completely or mainly substituted by fluorine,

R2

is 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl,

Ar

is phenyl, pyridyl, phenyl substituted by R3, R4 and R5 or pyridyl substituted by R6, R7, R8 and R9, where
R3  is halogen, carboxyl or 1-4C-alkoxycarbonyl,
R4  is hydrogen or halogen,
R5  is hydrogen or halogen,
R6  is halogen,
R7  is hydrogen or halogen, and
R8 and R9  are hydrogen,

and where R2 is not ethyl or 2,2-dimethylpropyl when R1 is methoxy,
the salts of these compounds, and the N-oxides of the pyridines and their salts with the proviso that the compound 2-Butyl-4-(3,5-dichloropyridin-4-ylaminocarbonyl)-7-methoxy-benzofuran or pharmaceutically acceptable salts thereof are excluded.

[0023] Compounds of the formula I which are particularly to be emphasized are those in which

R1

is 1-2C-alkoxy or 1-2C-alkoxy which is completely or mainly substituted by fluorine,

R2

is 1-4C-alkyl or 3-5C-cycloalkyl, and

Ar

is pyridyl, 3,5-dichloropyrid-4-yl, 2,6-difluorophenyl, 4-carboxy-2,6-dichlorophenyl, 4-carboxyphenyl, 4-methoxycarbonylphenyl, 4-ethoxycarbonylphenyl, 2,6-dichloro-4-methoxycarbonylphenyl or 2,6-dichloro-4-ethoxycarbonylphenyl.

the salts of these compounds, and the N-oxides of the pyridines and their salts with the proviso that the compound 2-Butyl-4-(3,5-dichloropyridin-4-ylaminocarbonyl)-7-methoxy-benzofuran or pharmaceutically acceptable salts thereof are excluded.

[0024] Preferred compounds of the formula I which are particularly to be emphasized are those in which

R1

is 1-2C-alkoxy or 1-2C-alkoxy which is completely or mainly substituted by fluorine,

R2

is 1-4C-alkyl or 3-5C-cycloalkyl, and

Ar

is pyridyl, 3,5-dichloropyrid-4-yl, 2,6-difluorophenyl, 4-carboxy-2,6-dichlorophenyl, 4-carboxyphenyl, 4-methoxycarbonylphenyl, 4-ethoxycarbonylphenyl, 2,6-dichloro-4-methoxycarbonylphenyl or 2,6-dichloro-4-ethoxycarbonylphenyl,

and where R2 is not ethyl when R1 is methoxy,
the salts of these compounds, and the N-oxides of the pyridines and their salts with the proviso that the compound 2-Butyl-4-(3,5-dichloropyridin-4-ylaminocarbonyl)-7-methoxy-benzofuran or pharmaceutically acceptable salts thereof are excluded.

[0025] Preferred compounds of the formula I are those in which

R1

is difluoromethoxy and

R2

is 1-4C-alkyl or 3-5C-cycloalkyl

or

R1

is methoxy and

R2

is 1-4C-alkyl or 3-5C-cycloalkyl

or

R1

is 1-2C-alkoxy or 1-2C-alkoxy which is complelely or mainly substituted by fluorine and

R2

is methyl, isopropyl or cyclopentyl and

Ar

is pyridyl, 3,5-dichloropyrid-4-yl, 2,6-difluorophenyl, 4-carboxy-2,6-dichlorophenyl, 4-carboxyphenyl, 4-methoxycarbonylphenyl, 4-ethoxycarbonylphenyl, 2,6-dichloro-4-methoxycarbonylphenyl or 2,6-dichloro-4-ethoxycarbonylphenyl,

the salts of these compounds, the N-oxides of the pyridines and their salts with the proviso that the compound 2-Butyl-4-(3,5-dichloropyridin-4-ylaminocarbonyl)-7-methoxy-benzofuran or pharmaceutically acceptable salts thereof are excluded.

[0026] Particularly preferred compounds of the formula I are those in which

R1

is difluoromethoxy,

R2

is 1-4C-alkyl or 3-5C-cycloalkyl and

Ar

is 3,5-dichloropyrid-4-yl, 2,6-dichloro-4-methoxycarbonylphenyl or 4-carboxy-2,6-dichlorophenyl or

R1

is methoxy,

R2

is 1-4C-alkyl or 3-5C-cycloalkyl and

Ar

is 3,5-dichloropyrid-4-yl, 4-pyridyl, 2,6-dichloro-4-methoxycarbonylphenyl or 4-carboxy-2,6-dichlorophenyl or

R1

is methoxy, ethoxy or difluoromethoxy and

R2

is methyl, isopropyl or cyclopentyl and

Ar

is 3,5-dichloropyrid-4-yl, 4-pyridyl, 2,6-dichloro-4-methoxycarbonylphenyl or 4-carboxy-2,6-dichlorophenyl,

the salts of these compounds, the N-oxides of the pyridines and their salts with the proviso that the compound 2-Butyl-4-(3,5-dichloropyridin-4-ylaminocarbonyl)-7-methoxy-benzofuran or pharmaceutically acceptable salts thereof are excluded.

[0027] Suitable salts of compounds of the formula I - depending on substitution - are all acid addition salts or all salts with bases. The pharmacologically tolerable salts of the inorganic and organic acids and bases customarily used in pharmacy may be mentioned particularly. Those suitable are on the one hand water-soluble and water-insoluble acid addition salts with acids such as, for example, hydrochloric acid, hydrobromic acid, phosphoric acid, nitric acid, sulfuric acid, acetic acid, citric acid, D-gluconic acid, benzoic acid, 2-(4-hydroxybenzoyl)benzoic acid, butyric acid, sulfosalicylic acid, maleic acid, lauric acid, malic acid, fumaric acid, succinic acid, oxalic acid, tartaric acid, embonic acid, stearic acid, toluenesulfonic acid, methanesulfonic acid or 3-hydroxy-2-naphthoic acid, the acids being employed in salt preparation - depending on whether it is a mono- or polybasic acid and depending on which salt is desired - in an equimolar quantitative ratio or one differing therefrom.

[0028] On the other hand, salts with bases are also especially suitable. Examples of salts with bases are alkali metal (lithium, sodium, potassium) or calcium, aluminum, magnesium, titanium, ammonium, meglumine or guanidinium salts, here also in salt preparation the bases being employed in an equimolar quantitative ratio or one differing therefrom.

[0029] Pharmacologically intolerable salts which can be initially obtained, for example, as process products in the preparation of the compounds according to the invention on an industrial scale, are converted into pharmacologically tolerable salts by processes known to the person skilled in the art.

[0030] The invention further relates to compounds of the formula II (see attached formula sheet) in which R1 and R2 have the meanings indicated above and X is a leaving group such as, for example, halogen.

[0031] The invention further relates to a process for the preparation of the compounds of the formula I and their salts, and also the N-oxides of the pyridines and their salts. The process comprises reacting compounds of the formula II, in which R1 and R2 have the meanings indicated above and X is a suitable leaving group, with amines H₂N-Ar, in which Ar has the meaning indicated above, and, if desired, then converting compounds of the formula I obtained into their salts and/or converting pyridines obtained into the N-oxides and, if desired, then converting into the salts, or, if desired, then converting salts of the compounds of the formula I obtained into the free compounds. If desired, compounds of the formula I obtained can be converted into further compounds of the formula I by derivatization. This can be carried out, for example, as described in the examples by the hydrolysis of ester groups to the corresponding acids.

[0032] The person skilled in the art is familiar on the basis of his expert knowledge with suitable leaving groups X. For example, suitable starting materials are acid halides of the formula II (X=Cl or Br). Otherwise, the reaction is carried out, for example, as described in the following examples, or in a manner familiar per se to the person skilled in the art (e.g. as described in the International Patent Application WO92/12961).

[0033] The N-oxidation is carried out in a manner which is likewise familiar to the person skilled in the art, e.g. with the aid of m-chloroperoxybenzoic acid in dichloromethane at room temperature. The person skilled in the art is familiar on the basis of his expert knowledge with reaction conditions which are specifically necessary for carrying out the process.

[0034] The isolation and purification of the substances according to the invention is carried out in a manner know per se, for example, by distilling off the solvent in vacuo and recrystallizing the residue obtained from a suitable solvent or subjecting it to one of the customary purification methods, such as, for example, column chromatography on suitable carrier material.

[0035] Salts are obtained by dissolving the free compound in a suitable solvent, e.g. in a chlorinated hydrocarbon, such as methylene chloride or chloroform, or a low molecular weight aliphatic alcohol (ethanol, isopropanol) which contains the desired acid or base, or to which the desired acid or base is then added. The salts are obtained by filtering, reprecipitating, precipitating with a nonsolvent for the addition salt or by evaporating the solvent.

[0036] Salts obtained can be converted by basification or by acidification into the free compounds, which can in turn be converted into salts. In this manner, pharmacologically intolerable salts can be converted into pharmacologically tolerable salts.

[0037] The amines H₂N-Ar, in which Ar has the meaning indicated above, are either known, or they can be prepared in a manner known to the person skilled in the art.

[0038] Compounds of the formula II in which R1 and R2 have the meanings indicated above can be prepared from corresponding compounds of the formula III (see attached formula sheet) by use of methods known to the person skilled in the art. If X in the formula II has the meaning chlorine, this can be carried out, for example, as described in the examples by reaction of the compounds of the formula III with thionyl chloride.

[0039] Compounds of the formula III are accessible from the corresponding compounds of the formula IV (see attached formula sheet) or from the corresponding compounds of the formula V (see attached formula sheet).

[0040] For example, compounds of the formula V in which R1 and R2 have the meanings indicated above are hydrolyzed using alkali metal hydroxides (optionally with addition of hydrogen peroxide) or appropriately substituted compounds of the formula IV in which R1 and R2 have the meanings indicated above are oxidized to the compounds III (e.g. as described in J. Org. Chem. 1986, 51, 569-571).

[0041] The compounds of the formulae IV and V in which R1 and R2 have the meanings indicated above are accessible (e.g. as described in Chem. Pharm. Bull, 1992, 40(5), 1148-1153 and Chem. Pharm. Bull. 1992, 40(8), 2002-2006) by a cesium fluoride-mediated Claisen rearrangement of the appropriately substituted compounds of the formula VI (see attached formula sheet). In the compounds of the formula VI, R1 has the meaning indicated above and R12 is cyano or formyl. The substituents R10 and R11 together with the carbon atom to which they are bonded form the corresponding substituent R2 after the Claisen rearrangement to the compounds of the formulae IV and V.

[0042] The compounds of the formula V can also be obtained from the appropriately substituted compounds of the formula IV by reaction with hydroxylamine in formic acid (e.g. as described in Synthesis 1979, 2, 112-113).

[0043] The compounds of the formula VI are either known or can be prepared in a manner known to the person skilled in the art, as described, for example, in Tetrahedron Lett. 1994, 35, 6405-6408.

[0044] The following examples serve to illustrate the invention in greater detail without restricting it. Further compounds of the formulae I and II, whose preparation is not described explicitly, can also be prepared in an analogous manner or in a manner familiar per se to the person skilled in the art using customary process techniques.

[0045] In the examples, m.p. is melting point, b.p. is boiling point, h is hour(s), RT is room temperature. The compounds and their salts, and the N-oxides of the pyridines and their salts mentioned in the examples are a preferred subject of the invention.

Examples

Final products

[0046] 

1. N-(3,5-Dichloropyrid-4-yl)-7-methoxy-2-methylbenzofuran-4-carboxamide
1.5 g of sodium hydride (80% strength) were added in small portions to a solution of 4.1 g of 4-amino-3,5-dichloropyridine in 50 ml of tetrahydrofuran and the suspension was stirred for about 0.5 h until evolution of hydrogen had ended. In parallel to this, 4.1 g of 7-methoxy-2-methylbenzofuran-4-carboxylic acid was stirred at 80°C for 3 h with 7.25 ml of thionyl chloride in 40 ml of toluene and the mixture was then evaporated in vacuo. About 20 ml of toluene were added to the residue and the solution was evaporated again in vacuo. The residue was then taken up in 50 ml of tetrahydrofuran and this solution was added dropwise at RT to the prepared suspension. After reaction was complete, the mixture was stirred into about 200 ml of ice water, treated with 30 ml of 2 N hydrochloric acid and extracted with ethyl acetate. This extract was dried over calcined sodium sulfate and evaporated in vacuo. The residue was crystallized from ethyl acetate/petroleum spirit (b.p. 50-80°C): m.p. 233°C.
Starting from the starting compounds described below, the final products described below are obtained by reaction of the corresponding benzofuran-4-carboxylic acids of the formula III with 4-amino-3,5-dichloropyridine or 4-aminopyridine analogously to Example 1:

2. N-(3,5-Dichloropyrid-4-yl)-7-methoxy-2-(1-methylethyl)benzofuran-4-carboxamide
M.p. 193°C.

3. N-(3,5-Dichloropyrid-4-yl)-7-ethoxy-2-(1-methylethyl)benzofuran-4-carboxamide
M.p. 180°C.

4. N-(3,5-Dichloropyrid-4-yl)-7-difluoromethoxy-2-(1-methylethyl)benzofuran-4-carboxamide
M.p. 157°C.

5. N-(3,5-Dichloropyrid-4-yl)-2-cyclopentyl-7-methoxybenzofuran-4-carboxamide
M.p. 174-175°C.

6. 7-Methoxy-2-(1-methylethyl)-N-(4-pyridyl)benzofuran-4-carboxamide
M.p. 186°C.

7. N-(2,6-Dichloro-4-methoxycarbonylphenyl)-7-methoxy-2-(1-methylethyl)benzofuran-4-carboxamide
2.0 g of triethylamine were added to a solution of 4.4 g of methyl 4-amino-3,5-dichlorobenzoate in 50 ml of tetrahydrofuran and the mixture was stirred (solution 1). In parallel to this, 4.7 g of 7-methoxy-2-(1-methylethyl)benzofuran-4-carboxylic acid were stirred at 80°C for 3 h with 10.0 ml of thionyl chloride in 40 ml of toluene and the mixture was then evaporated in vacuo. About 20 ml of toluene were added to the residue and the solution was evaporated again in vacuo. The residue was then taken up in 50 ml of tetrahydrofuran and this solution was added dropwise at RT to the prepared solution 1. After reaction was complete, the mixture was stirred into about 200 ml of ice water, treated with 30 ml of 2 N hydrochloric acid and extracted with ethyl acetate. This extract was dried over calcined sodium sulfate and evaporated in vacuo. The residue was crystallized from toluene: m.p. 175°C.
The following compound was prepared according to Example 7 from the appropriately substituted benzofuran-4-carboxylic acid of the formula III:

8. N-(2,6-Dichloro-4-methoxycarbonylphenyl)-7-difluoromethoxy-2-(1-methylethyl)benzofuran-4-carboxamide
M.p. 186°C.

9. N-(2,6-Dichloro-4-carboxyphenyl)-7-methoxy-2-(1-methylethyl)benzofuran-4-carboxamide
3.7 g of N-(2,6-Dichloro-4-methoxycarbonylphenyl)-7-methoxy-2-(1-methylethyl)benzofuran-4-carboxamide are refluxed for 15 min. in 20 ml of diethylene glycol and 30 ml of water in which 0.41 g of caustic soda is dissolved. The solution is diluted with water and acidified to pH 2 using 2 N sulfuric acid. The product precipitates in this process. It is filtered off with suction on a suction filter, washed free of acid with water and dried in vacuo: m.p. 279°C.
The compound of Example 8 is hydrolyzed in accordance with Example 9:

10. N-(2,6-Dichloro-4-carboxyphenyl)-7-difluoromethoxy-2-(1-methylethyl)benzofuran-4-carboxamide
M.p. 272°C.

Starting compounds

[0047] 

A. 7-Difluoromethoxy-2-(1-methylethyl)benzofuran-4-carboxylic acid
A solution of 0.88 g of sodium chlorite in 5 ml of water is added dropwise to 1.6 g of 7-difluoromethoxy-2-(1-methylethyl)benzofuran-4-carbaldehyde and 0.83 g of amidosulfuric acid dissolved in 15 ml of glacial acetic acid such that the internal temperature is kept between 15 and 20°C. The mixture is stirred for a further 1 h and then poured into 150 ml of ice water, and the precipitate formed is filtered off with suction and washed free of acid with water. For purification, the crude product is dissolved in half-concentrated, aqueous ammonia, and the aqueous solution is extracted with toluene and acidified to pH 1-2 using 2 N hydrochloric acid. The precipitate formed is filtered off with suction, washed free of acid with water and dried in vacuo: m.p. 169°C.
The following is prepared in the same manner starting from the corresponding benzofuran-4-carbaldehyde of the formula IV:

B. 7-Methoxy-2-(1-methylethyl)benzofuran-4-carboxlic acid
M.p. 166°C.

C. 7-Ethoxy-2-(1-methylethyl)benzofuran-4-carboxylic acid
0.5 g of 7-ethoxy-2-(1-methylethyl)benzofuran-4-carbonitrile is refluxed for 5 h in a solution of 10 ml of n-butanol, 30 ml of sodium hydroxide solution (50% strength) and 2.5 ml of hydrogen peroxide (30% strength). The mixture is then diluted with ice water, acidified to pH 1-2 using 2 N hydrochloric acid and the precipitate formed is filtered off with suction, washed free of acid with water and dried in vacuo: m.p. 186°C.
The following are prepared in the same manner starting from appropriate benzofuran-4-carbonitriles of the formula V:

D. 7-Methoxy-2-methylbenzofuran-4-carboxylic acid
M.p. 247°C.

E. 7-Methoxy-2-cyclopentylbenzofuran-4-carboxylic acid
M.p. 170-171°C.

F. 7-Difluoromethoxy-2-(1-methylethyl)benzofuran-4-carbaldehyde
5.5 g of 4-difluoromethoxy-3-(2-methyl-3-butyn-2-yloxy)benzaldehyde are refluxed with 7.2 g of cesium fluoride for 12 h with nitrogen aeration in 30 ml of N,N-diethylaniline. After cooling, the mixture is stirred into 300 ml of 4 N hydrochloric acid, the resulting emulsion is extracted three times with 50 ml of ethyl acetate, and the organic extracts are combined, dried over calcined potassium carbonate and evaporated in vacuo. The residue is chromatographed on silica gel using toluene. After evaporating the appropriate fractions, the title compound is obtained as an oil.
The following are obtained in the same manner starting from the corresponding benzaldehydes of the formula VI:

G. 7-Methoxy-2-(1-methylethyl)benzofuran-4-carbaldehyde
Oil.

H. 7-Methoxy-2-cyclopentylbenzofuran-4-carbaldehyde
Oil.

I. 7-Methoxy-2-methylbenzofuran-4-carbaldehdye
M.p. 69°C.

J. 7-Methoxy-2-methylbenzofuran-4-carbonitrile
27.6 g of 7-methoxy-2-methylbenzofuran-4-carbaldehyde are refluxed in 250 ml of formic acid for 1.5 h with 11.6 g of hydroxylamine and 19.7 g of sodium formate. The cooled solution is stirred into about 1.5 I of ice water, and the precipitate is filtered off with suction through a frit, washed free of acid with water and dried in vacuo: m.p. 103°C.
The following is prepared In the same manner starting from the corresponding benzofuran-4-carbaldehyde of the formula IV:

K. 2-Cyclopentyl-7-methoxybenzofuran-4-carbonitrile
Oil.

L. 7-Methoxy-2-(1-methylethyl)benzofuran-4-carbonitrile
5.3 g of 3-(1,1-dimethylprop-2-yn-1-yloxy)-4-methoxybenzonitrile and 5.3 g of cesium fluoride are refluxed for 12 h in 30 ml of N,N-diethylaniline with nitrogen aeration. After cooling, the mixture is stirred into 300 ml of 4 N hydrochloric acid, the resulting emulsion is extracted three times with 50 ml of ethyl acetate, and the organic extracts are combined, dried over calcined potassium carbonate and evaporated in vacuo. The residue is chromatographed on silica gel using toluene. After evaporating the corresponding fractions, the title compound is obtained as an oil.
The following is prepared in the same manner starting from 3-(1,1-dimethylprop-2-yn-1-yloxy)-4-ethoxybenzonitrile:

M. 7-Ethoxy-2-(1-methylethyl)benzofuran-4-carbonitrile
Oil.

N. 4-Difluoromethoxy-3-(2-methyl-3-butyn-2-yloxy)benzaldehyde

Solution 1:

[0048] 19.0 g of 2-methyl-3-butyn-2-ol are dissolved in 60 ml of dry acetonitrile with nitrogen aeration, the mixture is cooled to -5°C using ice/salt, 22.8 g of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) are added, the mixture is stirred at -5°C for 10 min. and then 24.4 g of trifluoroacetic anhydride are added dropwise such that the temperature of the solution is kept below 0°C. After addition is complete, the solution is stirred at -5° to -2°C for a further 30 min.

Solution 2:

[0049] 18.1 g of 4-difluoromethoxy-3-hydroxybenzaldehyde are dissolved in 60 ml of dry acetonitrile with nitrogen aeration, cooled to -5°C with ice/salt, 0.01 g of copper(I) chloride and 19.8 g of DBU are added and the mixture is stirred at -5°C for a further 30 min.

[0050] Solution 1 is then added dropwise to solution 2 in the course of 40 min, with stirring at -5°C and the mixture is stirred at 0°C for 5 h. The mixture is then evaporated in vacuo, the residue is taken up in 100 ml of water and the solution is extracted three times with 200 ml of toluene each time. The combined toluene extracts are washed successively with three times 50 ml of 1 N hydrochloric acid, two times 50 ml of 1 N sodium hydroxide solution, 50 ml of saturated sodium bicarbonate solution and finally with 50 ml of saturated sodium chloride solution, dried over calcined magnesium sulfate and concentrated in vacuo, and the residue is chromatographed on silica gel using a mixture of cyclohexane/ethanol (97:3). After evaporating the appropriate fractions 4-difluoromethoxy-3-(2-methyl-3-butyn-2-yloxy)benzaldehyde is obtained as an oil.

[0051] In the same manner, 3-hydroxy-4-methoxybenzaldehyde and 4-ethoxy-3-hydroxybenzaldehyde are reacted with appropriate 1-ethynyl alcohols according to Example M:

O. 3-(2-Methyl-3-butyn-2-yloxy)-4-methoxybenzaldehyde
Oil

P. 3-(1-Ethynylcyclopentyloxy)-4-methoxybenzaldehyde
M.p. 91.5-93°C.

Q. 4-Methoxy-3-(2-propyn-1-yloxy)benzaldehdye
M.p. 74.5°C.

[0052] The following benzonitriles of the formula VI are prepared in the same manner from 3-hydroxy-4-methoxybenzonitrile or 4-ethoxy-3-hydroxybenzonitrile:

R. 3-(1,1-Dimethylprop-2-yn-1-yloxy)-4-methoxybenzonitrile
M.p. 103°C.

S. 4-Ethoxy-3-(1,1-dimethylprop-2-yn-1-yloxy)benzonitrile
M.p. 60°C.

T. 3-(1-Ethynyl-1-cyclopentyloxy)-4-methoxybenzonitrile
M.p. 67°C.

Commercial utility

[0053] The compounds according to the invention have useful pharmacological properties which make them commercially utilizable. As selective cyclic nucleotide phosphodiesterase (PDE) inhibitors (namely of type IV), they are suitable on the one hand as bronchial therapeutics (for the treatment of airway obstructions on account of their dilating action but also on account of their respiratory rate- or respiratory drive-increasing action) and for the rectification of erectile dysfunction on account of the vasodilating action, but on the other hand especially for the treatment of disorders, in particular of inflammatory nature, e.g. of the airways (asthma prophylaxis), of the skin, of the intestine, of the eyes and of the joints, which are mediated by mediators such as histamine, PAF (platelet-activating factor), arachidonic acid derivatives such as leukotrienes and prostaglandins, cytokines, interleukins, chemokines, alpha-, beta- and gamma-interferon, tumor necrosis factor (TNF) or oxygen radicals and proteases. The compounds according to the invention are distinguished here by a low toxicity, a good enteral absorption (high bioavailability), a wide therapeutic range and the absence of significant side effects.

[0054] On account of their PDE-inhibiting properties, the compounds according to the invention can be employed in human and veterinary medicine as therapeutics, it being possible to use them, for example, for the treatment and prophylaxis of the following diseases: acute and chronic (in particular inflammatory and allergen-induced) airway disorders of various origin (bronchitis, allergic bronchitis, bronchial asthma); dermatoses (in particular of proliferative, inflammatory and allergic nature) such as, for example, psoriasis (vulgaris), toxic and allergic contact eczema, atopic eczema, seborrheic eczema, lichen simplex, sunburn, pruritus in the anogenital region, alopecia areata, hypertrophic scars, discoid lupus erythematosus, follicular and wide-spread pyodermias, endogenous and exogenous acne, acne rosacea, and other proliferative, inflammatory and allergic skin disorders; disorders which are based on an excessive release of TNF and leukotrienes, e.g. disorders of the arthritic type (rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis and other arthritic conditions), disorders of the immune system (AIDS, multiple sclerosis), types of shock [septic shock, endotoxin shock, gram-negative sepsis, toxic shock syndrome and ARDS (adult respiratory distress syndrome)], and generalized inflammations in the gastrointestinal region (Crohn's disease and ulcerative colitis); disorders which are based on allergic and/or chronic, faulty immunological reactions in the region of the upper airways (pharynx, nose) and the adjacent regions (paranasal sinuses, eyes), such as, for example, allergic rhinitis/sinusitis, chronic rhinitis/sinusitis, allergic conjunctivitis and nasal polyps; but also disorders of the heart which can be treated by PDE inhibitors, such as, for example, cardiac insufficiency, or disorders which can be treated on account of the tissue-relaxing action of the PDE inhibitors, such as, for example, erectile dysfunction or colics of the kidneys and of the ureters in connection with kidney stones; or alternatively disorders of the CNS, such as, for example, depressions or arteriosclerotic dementia.

[0055] The invention further relates to a method for the treatment of mammals, including humans, which are suffering from one of the abovementioned diseases. The method comprises administering to the sick mammal a therapeutically active and pharmacologically tolerable amount of one or more of the compounds according to the invention.

[0056] The invention further relates to the compounds according to the invention for use in the treatment and/or prophylaxis of the diseases mentioned.

[0057] The invention also relates to the use of the compounds according to the invention for the production of medicaments which are employed for the treatment and/or prophylaxis of the diseases mentioned.

[0058] The invention furthermore relates to medicaments for the treatment and/or prophylaxis of the diseases mentioned, which contain one or more of the compounds according to the invention.

[0059] The medicaments are prepared by processes known per se which are familiar to the person skilled in the art. As medicaments, the compounds according to the invention (= active compounds) are either employed as such, or preferably in combination with suitable pharmaceutical auxiliaries, e.g. in the form of tablets, coated tablets, capsules, suppositories, patches, emulsions, suspensions, gels or solutions, the active compound content advantageously being between 0.1 and 95%.

[0060] The person skilled in the art is familiar on account of his expert knowledge with the auxiliaries which are suitable for the desired pharmaceutical formulations. Beside solvents, gel-forming agents, ointment bases and other active compound excipients, it is possible to use, for example, antioxidants, dispersants, emulsifiers, preservatives, solubilizers or permeation promoters.

[0061] For the treatment of disorders of the respiratory tract, the compounds according to the invention are preferably also administered by inhalation. To this end, these are either administered directly as powders (preferably in micronized form) or by atomizing solutions or supsensions which contain them. With respect to the preparations and administration forms, reference is made, for example, to the details in European Patent 163 965.

[0062] For the treatment of dermatoses, the administration of the compounds according to the invention is in particular carried out in the form of those medicaments which are suitable for topical application. For the production of the medicaments, the compounds according to the invention (= active compounds) are preferably mixed with suitable pharmaceutical auxiliaries and processed further to give suitable pharmaceutical formulations. Suitable pharmaceutical formulations are, for example, powders, emulsions, suspensions, sprays, oils, ointments, fatty ointments, creams, pastes, gels or solutions.

[0063] The medicaments according to the invention are prepared by methods known per se. The dosage of the active compounds is carried out in the order of magnitude customary for PDE inhibitors. Thus topical application forms (such as, for example, ointments) for the treatment of dermatoses contain the active compounds in a concentration of, for example, 0.1-99%. The dose for administration by inhalation is customarily between 0.01 and 1 mg per puff. The customary dose in the case of systemic therapy (p.o. or i.v.) is between 0.1 and 200 mg per application.

Biological investigations

[0064] In the investigation of PDE IV inhibition at the cellular level, the activation of inflammatory cells is ascribed particular importance. An example is the FMLP (N-formyl-methionyl-leucyl-phenylalanine)-induced superoxide production of neutrophilic granulocytes, which can be measured as luminol-potentiated chemoluminescence. [Mc Phail LC, Strum SL, Leone PA and Sozzani S, The neutrophil respiratory burst mechanism. In "Immunology Series" 1992, 57, 47-76; ed. Coffey RG (Marcel Decker, Inc., New York-Basle-Hong Kong)].

[0065] Substances which inhibit chemoluminescence and cytokine secretion and the secretion of proinflammatory mediators of inflammatory cells, in particular neutrophilic and eosinophilic granulocytes, are those which inhibit PDE IV. This isoenzyme of the phosphodiesterase families is particularly represented in granulocytes. Its inhibition leads to the raising of the intracellular cyclic AMP concentration and thus to the inhibition of cellular activation. PDE IV inhibition by the substances according to the invention is thus a central indicator of the suppression of inflammatory processes. (Giembycz MA, Could isoenzyme-selective phosphodiesterase inhibitors render bronchodilatory therapy redundant in the treatment of bronchial asthma?. Biochem Pharmacol 1992, 43, 2041-2051; Torphy TJ et al., Phosphodiesterase inhibitors: new opportunities for treatment of asthma. Thorax 1991, 46, 512-523; Schudt C et al., Zardaverine: a cyclic AMP PDE III/IV inhibitor. In "New Drugs for Asthma Therapy", 379-402, Birkhäuser Verlag Basle 1991; Schudt C et al., Influence of selective phospho-diesterase inhibitors on human neutrophil functions and levels of CAMP and Ca_l. Naunyn-Schmiedebergs Arch Pharmacol 1991, 344, 682-690; Nielson CP et al., Effects of selective phosphodiesterase inhibitors on polymorphonuclear leucocyte respiratory burst. J Allergy Clin Immunol 1990, 86, 801-808; Schade et al., The specific type III and IV phosphodlesterase inhibitor zardaverine suppress formation of tumor necrosis factor by macrophages. European Journal of Pharmacology 1993, 230, 9-14).

1. Inhibition of PDE IV activity

Methodology

[0066] The activity test was carried out according to the method of Bauer and Schwabe, which was adapted to microtiter plates (Naunyn-Schmiedeberg's Arch. Pharmacol, 1980, 311, 193-198). Here the PDE reaction takes place in the first step. In a second step, the 5'-nucleotide formed is cleaved to the uncharged nucteoside by a 5'-nucleotidase of the snake venom of Ophiophagus hannah (king cobra). In the third step, the nucleoside is separated from the remaining charged substrate on ion-exchange columns. The columns are eluted with 2 ml of 30 mM ammonium formate (pH 6.0) directly into minivials to which is additionally added 2 ml of scintillator fluid for counting.

[0067] The inhibitory values determined for the compounds according to the invention can be seen from the following Table A, in which the numbers of the compounds correspond to the numbers of the examples.

Table A

Inhibition of PDE IV activity
Compound	-log IC50
1	8.42
2	9.28
3	8.18
4	9.72
5	8.80

Claims

1. A compound of the formula I

in which

R1   is 1-2C-alkoxy or 1-2C-alkoxy which is completely or mainly substituted by fluorine,

R2   is 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl,

Ar   is phenyl, pyridyl, phenyl which is substituted by R3, R4 and R5 or pyridyl which is substituted by R6, R7, R8 and R9, where

R3   is hydroxyl, halogen, cyano, carboxyl, trifluoromethyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyl, 1-4C-alkylcarbonyloxy, amino, mono- or di-1-4C-alkylamino or 1-4C-alkylcarbonylamino,

R4   is hydrogen, hydroxyl, halogen, amino, trifluoromethyl, 1-4C-alkyl or 1-4C-alkoxy,

R5   is hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy,

R6   is hydroxyl, halogen, cyano, carboxyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl or amino,

R7   is hydrogen, halogen, amino or 1-4C-alkyl,

R8   is hydrogen or halogen and

R9   is hydrogen or halogen,

the salts of this compound, and the N-oxides of the pyridines and their salts, with the proviso that the compound 2-Butyl-4-(3,5-dichloropyridin-4-ylaminocarbonyl)-7-methoxybenzofuran or a pharmaceutically acceptable salt thereof is excluded.

2. A compound of the formula I as claimed in claim 1, in which

R1   is 1-2C-alkoxy or 1-2C-alkoxy which is completely or mainly substituted by fluorine,

R2   is 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloalkylmethyl,

Ar   is phenyl, pyridyl, phenyl which is substituted by R3, R4 and R5 or pyridyl which is substituted by R6, R7, R8 and R9, where

R3   is hydroxyl, halogen, cyano, carboxyl, trifluoromethyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl, 1-4C-alkylcarbonyl, 1-4C-alkylcarbonyloxy, amino, mono- or di-1-4C-alkylamino or 1-4C-alkylcarbonylamino,

R4   is hydrogen, hydroxyl, halogen, amino, trifluoromethyl, 1-4C-alkyl or 1-4C-alkoxy,

R5   is hydrogen, halogen, 1-4C-alkyl or 1-4C-alkoxy,

R6   is hydroxyl, halogen, cyano, carboxyl, 1-4C-alkyl, 1-4C-alkoxy, 1-4C-alkoxycarbonyl or amino,

R7   is hydrogen, halogen, amino or 1-4C-alkyl,

R8   is hydrogen or halogen and

R9   is hydrogen or halogen,

and where R2 is not ethyl or 2,2-dimethylpropyl when R1 is methoxy,
the salts of this compound, and the N-oxides of the pyridines and their salts, with the proviso that the compound 2-Butyl-4-(3,5-dichloropyridin-4-ylaminocarbonyl)-7-methoxybenzofuran or a pharmaceutically acceptable salt thereof is excluded.

3. A compound of the formula I as claimed in claim 1, in which

R1   is 1-2C-alkoxy or 1-2C-alkoxy which is completely or mainly substituted by fluorine,

R2   is 1-7C-alkyl, 3-7C-cycloalkyl or 3-7C-cycloakylmethyl,

Ar   is phenyl, pyridyl, phenyl substituted by R3, R4 and R5 or pyridyl substituted by R6, R7, R8 and R9, where

R3   is halogen, carboxyl or 1-4C-alkoxycarbonyl,

R4   is hydrogen or halogen,

R5   is hydrogen or halogen,

R6   is halogen,

R7   is hydrogen or halogen, and

R8 and R9   are hydrogen,

and where R2 is not ethyl or 2,2-dimethylpropyl when R1 is methoxy,
the salts of this compound, and the N-oxides of the pyridines and their salts, with the proviso that the compound 2-Butyl-4-(3,5-dichloropyridin-4-ylaminocarbonyl)-7-methoxybenzofuran or a pharmaceutically acceptable salt thereof is excluded.

4. A compound of the formula 1 as claimed in claim 1, in which

R1   is 1-2C-alkoxy or 1-2C-alkoxy which is completely or mainly substituted by fluorine,

R2   is 1-4C-alkyl or 3-5C-cycloalkyl, and

Ar   is pyridyl, 3,5-dichloropyrid-4-yl, 2,6-difluorophenyl, 4-carboxy-2,6-dichlorophenyl, 4-carboxyphenyl, 4-methoxycarbonylphenyl, 4-ethoxycarbonylphenyl, 2,6-dichloro-4-methoxycarbonylphenyl or 2,6-dichloro-4-ethoxycarbonylphenyl,

and where R2 is not ethyl, when R1 is methoxy,
the salts of this compound, and the N-oxides of the pyridines and their salts, with the proviso that the compound 2-Butyl-4-(3,5-dichloropyridin-4-ylaminocarbonyl)-7-methoxybenzofuran or a pharmaceutically acceptable salt thereof is excluded.

5. A compound of the formula I as claimed in claim 1, in which

R1   is difluoromethoxy and

R2   is 1-4C-alkyl or 3-5C-cycloalkyl

or

R1   is 1-2C-alkoxy or 1-2C-alkoxy which is completely or mainly substituted by fluorine and

R2   is methyl, isopropyl or cyclopentyl and

Ar   is pyridyl, 3,5-dichloropyrid-4-yl, 2,6-difluorophenyl, 4-carboxy-2,6-dichlorophenyl, 4-carboxyphenyl, 4-methoxycarbonylphenyl, 4-ethoxycarbonylphenyl, 2,6-dichloro-4-methoxycarbonylphenyl or 2,6-dichloro-4-ethoxycarbonylphenyl,

the salts of this compound, the N-oxides of the pyridines and their salts.

6. A compound of the formula I as claimed in claim 1, in which

R1   is difluoromethoxy,

R2   is 1-4C-alkyl or 3-5C-cycloalkyl and

Ar   is 3,5-dichloropyrid-4-yl, 2,6-dichloro-4-methoxycarbonylphenyl or 4-carboxy-2,6-dichlorophenyl or

R1   is methoxy, ethoxy or difluoromethoxy and

R2   is methyl, isopropyl or cyclopentyl and

Ar   is 3,5-dichloropyrid-4-yl, 4-pyridyl, 2,6-dichloro-4-methoxycarbonylphenyl or 4-carboxy-2,6-dichlorophenyl,

the salts of this compound, the N-oxides of the pyridines and their salts.

7. A medicament comprising one or more compounds as claimed in claim 1, together with customary pharmaceutical auxiliaries and/or excipients.

8. A compound as claimed in claim 1 for use in the treatment of diseases.

9. The use of compounds as claimed in claim 1 for the production of medicaments for the treatment of airway disorders.

Ansprüche

1. Verbindungen der Formel I,

worin

R1   1-2C-Alkoxy oder ganz oder überwiegend durch Fluor substituiertes 1-2C-Alkoxy bedeutet,

R2   1-7C-Alkyl, 3-7C-Cycloalkyl oder 3-7C-Cycloalkylmethyl bedeutet,

Ar   Phenyl, Pyridyl, durch R3, R4 und R5 substituiertes Phenyl oder durch R6, R7, R8 und R9 substituiertes Pyridyl bedeutet, wobei

R3   Hydroxy, Halogen, Cyano, Carboxyl, Trifluormethyl, 1-4C-Alkyl, 1-4C-Alkoxy, 1-4C-Alkoxycarbonyl, 1-4C-Alkylcarbonyl, 1-4C-Alkylcarbonyloxy, Amino, Mono- oder Di-1-4C-alkylamino oder 1-4C-Alkylcarbonylamino,

R4   Wasserstoff, Hydroxy, Halogen, Amino, Trifluormethyl, 1-4C-Alkyl oder 1-4C-Alkoxy,

R5   Wasserstoff, Halogen, 1-4C-Alkyl oder 1-4C-Alkoxy,

R6   Hydroxy, Halogen, Cyano, Carboxyl, 1-4C-Alkyl, 1-4C-Alkoxy, 1-4C-Alkoxycarbonyl oder Amino,

R7   Wasserstoff, Halogen, Amino oder 1-4C-Alkyl,

R8   Wasserstoff oder Halogen und

R9   Wasserstoff oder Halogen bedeutet,

die Salze dieser Verbindungen sowie die N-Oxide der Pyridine und deren Salze, mit der Bedingung, dass die Verbindung 2-Butyl-4-(3,5-dichlorpyridin-4-ylaminocarbonyl)-7-methoxybenzofuran oder ein pharmazeutisch verträgliches Salz davon ausgenommen ist.

2. Verbindungen der Formel I nach Anspruch 1, in denen

R1   1-2C-Alkoxy oder ganz oder überwiegend durch Fluor substituiertes 1-2C-Alkoxy bedeutet,

R2   1-7C-Alkyl, 3-7C-Cycloalkyl oder 3-7C-Cycloalkylmethyl bedeutet,

Ar   Phenyl, Pyridyl, durch R3, R4 und R5 substituiertes Phenyl oder durch R6, R7, R8 und R9 substituiertes Pyridyl bedeutet, wobei

R3   Hydroxy, Halogen, Cyano, Carboxyl, Trifluormethyl, 1-4C-Alkyl, 1-4C-Alkoxy, 1-4C-Alkoxycarbonyl, 1-4C-Alkylcarbonyl, 1-4C-Alkylcarbonyloxy, Amino, Mono- oder Di-1-4C-alkylamino oder 1-4C-Alkylcarbonylamino,

R4   Wasserstoff, Hydroxy, Halogen, Amino, Trifluormethyl, 1-4C-Alkyl oder 1-4C-Alkoxy,

R5   Wasserstoff, Halogen, 1-4C-Alkyl oder 1-4C-Alkoxy,

R6   Hydroxy, Halogen, Cyano, Carboxyl, 1-4C-Alkyl, 1-4C-Alkoxy, 1-4C-Alkoxycarbonyl oder Amino,

R7   Wasserstoff, Halogen, Amino oder 1-4C-Alkyl,

R8   Wasserstoff oder Halogen und

R9   Wasserstoff oder Halogen bedeutet,

und in denen R2 nicht Ethyl oder 2,2-Dimethylpropyl bedeutet, wenn R1 Methoxy bedeutet,
die Salze dieser Verbindungen sowie die N-Oxide der Pyridine und deren Salze, mit der Bedingung, dass die Verbindung 2-Butyl-4-(3,5-dichlorpyridin-4-ylaminocarbonyl)-7-methoxybenzofuran oder ein pharmazeutisch verträgliches Salz davon ausgenommen ist.

3. Verbindungen der Formel I nach Anspruch 1, in denen

R1   1-2C-Alkoxy oder ganz oder überwiegend durch Fluor substituiertes 1-2C-Alkoxy bedeutet,

R2   1-7C-Alkyl, 3-7C-Cycloalkyl oder 3-7C-Cycloalkylmethyl bedeutet,

Ar   Phenyl, Pyridyl, durch R3, R4 und R5 substituiertes Phenyl oder durch R6, R7, R8 und R9 substituiertes Pyridyl bedeutet, wobei

R3   Halogen, Carboxyl oder 1-4C-Alkoxycarbonyl,

R4   Wasserstoff oder Halogen,

R5   Wasserstoff oder Halogen,

R6   Halogen,

R7   Wasserstoff oder Halogen und

R8 und R9   Wasserstoff bedeuten,

und in denen R2 nicht Ethyl oder 2,2-Dimethylpropyl bedeutet, wenn R1 Methoxy bedeutet,
die Salze dieser Verbindungen sowie die N-Oxide der Pyridine und deren Salze, mit der Bedingung, dass die Verbindung 2-Butyl-4-(3,5-dichlorpyridin-4-ylaminocarbonyl)-7-methoxybenzofuran oder ein pharmazeutisch verträgliches Salz davon ausgenommen ist.

4. Verbindungen der Formel I nach Anspruch 1, in denen

R1   1-2C-Alkoxy oder ganz oder überwiegend durch Fluor substituiertes 1-2C-Alkoxy bedeutet,

R2   1-4C-Alkyl oder 3-5C-Cycloalkyl bedeutet und

Ar   Pyridyl, 3,5-Dichlorpyrid-4-yl, 2,6-Difluorphenyl, 4-Carboxy-2,6-dichlorphenyl, 4-Carboxyphenyl, 4-Methoxycarbonylphenyl, 4-Ethoxycarbonylphenyl, 2,6-Dichlor-4-methoxycarbonylphenyl oder 2,6-Dichlor-4-ethoxycarbonylphenyl bedeutet,

und in denen R2 nicht Ethyl bedeutet, wenn R1 Methoxy bedeutet,
die Salze dieser Verbindungen sowie die N-Oxide der Pyridine und deren Salze, mit der Bedingung, dass die Verbindung 2-Butyl-4-(3,5-dichlorpyridin-4-ylaminocarbonyl)-7-methoxybenzofuran oder ein pharmazeutisch verträgliches Salz davon ausgenommen ist.

5. Verbindungen der Formel I nach Anspruch 1, in denen

R1   Difluormethoxy und

R2   1-4C-Alkyl oder 3-5C-Cycloalkyl

oder

R1   1-2C-Alkoxy oder ganz oder überwiegend durch Fluor substituiertes 1-2C-Alkoxy und

R2   Methyl, Isopropyl oder Cyclopentyl bedeutet und

Ar   Pyridyl, 3,5-Dichlorpyrid-4-yl, 2,6-Difluorphenyl, 4-Carboxy-2,6-dichlorphenyl, 4-Carboxyphenyl, 4-Methoxycarbonylphenyl, 4-Ethoxycarbonylphenyl, 2,6-Dichlor-4-methoxycarbonylphenyl oder 2,6-Dichlor-4-ethoxycarbonylphenyl bedeutet,

die Salze dieser Verbindungen, die N-Oxide der Pyridine und deren Salze.

6. Verbindungen der Formel I nach Anspruch 1, in denen

R1   Difluormethoxy,

R2   1-4C-Alkyl oder 3-5C-Cycloalkyl und

Ar   3,5-Dichlorpyrid-4-yl, 2,6-Dichlor-4-methoxycarbonylphenyl oder 4-Carboxy-2,6-dichlorphenyl oder

R1   Methoxy, Ethoxy oder Difluormethoxy und

R2   Methyl, Isopropyl oder Cyclopentyl und

Ar   3,5-Dichlorpyrid-4-yl, 4-Pyridyl, 2,6-Dichlor-4-methoxycarbonylphenyl oder 4-Carboxy-2,6-dichlorphenyl bedeutet,

die Salze dieser Verbindungen, die N-Oxide der Pyridine und deren Salze.

7. Arzneimittel enthaltend eine oder mehrere Verbindungen nach Anspruch 1, zusammen mit üblichen pharmazeutischen Hilfs- und/oder Trägerstoffen.

8. Verbindungen nach Anspruch 1 zur Anwendung bei der Behandlung von Krankheiten.

9. Verwendung von Verbindungen nach Anspruch 1 zur Herstellung von Arzneimitteln für die Behandlung von Atemwegserkrankungen.

Revendications

1. Composé de formule (I):

dans laquelle :

R1   représente un groupe alcoxy en C_1-2 ou alcoxy en C_1-2 qui est complètement ou essentiellement substitué par du fluor,

R2   représente un groupe alkyle en C_1-7, cycloalkyle en C_3-7 ou (cycloalkyl en C_3-7)méthyle,

Ar   représente un groupe phényle, pyridyle, phényle qui est substitué par R3, R4 et R5, ou pyridyle qui est substitué par R6, R7, R8 et R9, où

R3   représente un groupe hydroxy, un atome d'halogène, un groupe cyano, carboxy, trifluorométhyle, alkyle en C_1-4, alcoxy en C_1-4, (alcoxy en C_1-4)carbonyle, (alkyl en C_1-4)carbonyle, (alkyl en C_1-4)carbonyloxy, amino, mono- ou di-(alkyl en C_1-4)amino ou (alkyl en C_1-4)carbonylamino,

R4   représente un atome d'hydrogène, un groupe hydroxy, un atome d'halogène, un groupe amino, trifluorométhyle, alkyle en C_1-4, ou alcoxy en C_1-4,

R5   représente un atome d'hydrogène, un atome d'halogène, un groupe alkyle en C_1-4, ou alcoxy en C_1-4,

R6   représente un groupe hydroxy, un atome d'halogène, un groupe cyano, carboxy, alkyle en C_1-4, alcoxy en C_1-4, (alcoxy en C_1-4)carbonyle, ou amino,

R7   représente un atome d'hydrogène, un atome d'halogène, un groupe amino ou alkyle en C_1-4,

R8   représente un atome d'hydrogène ou un atome d'halogène, et

R9   représente un atome d'hydrogène ou un atome d'halogène,

sels de ce composé, et N-oxydes des pyridines et leurs sels, à condition que le composé 2-butyl-4-(3,5-dichloropyridin-4-ylaminocarbonyl)-7-méthoxybenzofurane ou un de ces sels pharmaceutiquement acceptables soit exclu.

2. Composé de formule I selon la revendication 1, dans lequel :

R1   représente un groupe alcoxy en C_1-2 ou alcoxy en C_1-2 qui est complètement ou essentiellement substitué par du fluor,

R2   représente un groupe alkyle en C_1-7, cycloalkyle en C_3-7 ou (cycloalkyl en C_3-7)méthyle,

Ar   représente un groupe phényle, pyridyle, phényle qui est substitué par R3, R4 et R5, ou pyridyle qui est substitué par R6, R7, R8 et R9, où

R3   représente un groupe hydroxy, un atome d'halogène, un groupe cyano, carboxy, trifluorométhyle, alkyle en C_1-4, alcoxy en C_1-4, (alcoxy en C_1-4)carbonyle, (alkyl en C_1-4) carbonyle, (alkyl en C_1-4)carbonyloxy, amino, mono- ou di-(alkyl en C_1-4)amino ou (alkyl en C_1-4)carbonylamino,

R4   représente un atome d'hydrogène, un groupe hydroxy, un atome d'halogène, un groupe amino, trifluorométhyle, alkyle en C_1-4, ou alcoxy en C_1-4,

R5   représente un atome d'hydrogène, un atome d'halogène, un groupe alkyle en C_1-4, ou alcoxy en C_1-4,

R6   représente un groupe hydroxy, un atome d'halogène, un groupe cyano, carboxy, alkyle en C_1-4, alcoxy en C_1-4, (alcoxy en C_1-4)carbonyle ou amino,

R7   représente un atome d'hydrogène, un atome d'halogène, un groupe amino ou alkyle en C_1-4,

R8   représente un atome d'hydrogène ou un atome d'halogène, et

R9   représente un atome d'hydrogène ou un atome d'halogène,

et où R2 ne représente pas un groupe éthyle ou 2,2-diméthylpropyle quand R1 représente un groupe méthoxy,
sels de ce composé, et N-oxydes des pyridines et leurs sels, à condition que le composé 2-butyl-4-(3,5-dichloropyridin-4-ylaminocarbonyl)-7-méthoxybenzofurane ou un de ces sels pharmaceutiquement acceptables soit exclu.

3. Composé de formule I selon la revendication 1, dans lequel :

R1   représente un groupe alcoxy en C_1-2 ou alcoxy en C_1-2 qui est complètement ou essentiellement substitué par du fluor,

R2   représente un groupe alkyle en C_1-7, cycloalkyle en C_3-7 ou (cycloalkyl en C_3-7)méthyle,

Ar   représente un groupe phényle, pyridyle, phényle qui est substitué par R3, R4 et R5, ou pyridyle qui est substitué par R6, R7, R8 et R9, où

R3   représente un atome d'halogène, un groupe carboxy ou (alcoxy en C_1-4)carbonyle,

R4   représente un atome d'hydrogène ou un atome d'halogène,

R5   représente un atome d'hydrogène ou un atome d'halogène,

R6   représente un atome d'halogène,

R7   représente un atome d'hydrogène ou un atome d'halogène, et

R8 et R9   représentent un atome d'hydrogène,

et où R2 ne représente pas un groupe éthyle ou 2,2-diméthylpropyle quand R1 représente un groupe méthoxy, sels de ce composé, et N-oxydes des pyridines et leurs sels, à condition que le composé 2-butyl-4-(3,5-dichloropyridin-4-ylaminocarbonyl)-7-méthoxybenzofurane ou un de ces sels pharmaceutiquement acceptables soit exclu.

4. Composé de formule I selon la revendication 1, dans lequel :

R1   représente un groupe alcoxy en C_1-2 ou alcoxy en C_1-2 qui est complètement ou essentiellement substitué par du fluor,

R2   représente un groupe alkyle en C_1-4 ou cycloalkyle en C_3-5,

Ar   représente un groupe pyridyle, 3,5-dichloropyrid-4-yle, 2,6-difluorophényle, 4-carboxy-2,6-dichlorophényle, 4-carboxyphényle, 4-méthoxycarbonylphényle, 4-éthoxycarbonylphényle, 2,6-dichloro-4-méthoxycarbonylphényle ou 2,6-dichloro-4-éthoxycarbonylphényle,

et où R2 ne représente pas un groupe éthyle quand R1 représente un groupe méthoxy,
sels de ce composé, et N-oxydes des pyridines et leurs sels, à condition que le composé 2-butyt-4-(3,5-dichloropyridin-4-ylaminocarbonyl)-7-méthoxybenzofurane ou un de ces sels pharmaceutiquement acceptables soit exclu.

5. Composé de formule I selon la revendication 1, dans lequel :

R1   représente un groupe difluorométhoxy,

R2   représente un groupe alkyle en C_1-4 ou cycloalkyle en C_3-5,

ou

R1   représente un groupe alcoxy en C_1-2 ou alcoxy en C_1-2 qui est complètement ou essentiellement substitué par du fluor,

R2   représente un groupe méthyle, isopropyle ou cyclopentyle, et

Ar   représente un groupe pyridyle, 3,5-dlchloropyrid-4-yle, 2,6-difluorophényle, 4-carboxy-2,6-dichlorophényle, 4-carboxyphényle, 4-méthoxycarbonylphényle, 4-éthoxycarbonylphényle, 2,6-dichloro-4-méthoxycarbonylphényle ou 2,6-dichloro-4-éthoxycarbonylphényle,

sels de ce composé, et N-oxydes des pyridines et leurs sels.

6. Composé de formule I selon la revendication 1, dans lequel :

R1   représente un groupe difluorométhoxy,

R2   représente un groupe alkyle en C_1-4 ou cycloalkyle en C_3-5, et

Ar   représente un groupe 3,5-dichloropyrid-4-yle, 2,6-dichloro-4-méthoxycarbonylphényle ou 4-carboxy-2,6-dichlorophényle,

ou

R1   représente un groupe méthoxy, éthoxy ou difluorométhoxy,

R2   représente un groupe méthyle, isopropyle ou cyclopentyle, et

Ar   représente un groupe 3,5-dichloropyrid-4-yle, 4-pyridyle, 2,6-dichloro-4-méthoxycarbonylphényle ou 4-carboxy-2,6-dichlorophényle,

sels de ce composé, et N-oxydes des pyridines et leurs sels.

7. Médicament comprenant un ou plusieurs composés selon la revendication 1, en combinaison avec des composés auxiliaires et/ou excipients conformes à l'usage pharmaceutique.

8. Composé selon la revendication 1, destiné à être utilisé dans le traitement de maladies.

9. Utilisation de composés selon la revendication 1, pour la production de médicaments destinés au traitement des troubles des voies respiratoires.

Drawing