(19)

(11)

EP 0 923 603 A1

(12)

(43) Date of publication: 23.06.1999 Bulletin 1999/25 (21) Application number: 97930366.0 (22) Date of filing: 16.07.1997

(51) International Patent Classification (IPC):  A61K 47/ 48( . ) C07K 5/ 072( . ) (86) International application number: PCT/DK1997/000312 (87) International publication number: WO 1998/002451 (22.01.1998 Gazette 1998/03)

(84) Designated Contracting States: DE DK ES FR GB IT SE (30) Priority: 16.07.1996 DK 19960000790 (71) Applicant: NOVO NORDISK A/S 2880 Bagsvaerd (DK)	(72) Inventors: TAUB, Mitchell, Ethan DK-2200 Copenhagen N (DK) FROEKJAER, Sveb DK-2840 Holte (DK) LARSEN, Bjarne, Due DK-2700 Broenshoej (DK) STEFFANSEN, Inge-Bente, Dalsgard DK-2000 Frederiksberg (DK) (74) Representative: Plougmann, Vingtoft & Partners A/S  Sankt Annae Plads 11, P.O. Box 3007 1021 Copenhagen K 1021 Copenhagen K (DK)