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EP 0 923 647 A1

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(43) Date of publication: 23.06.1999 Bulletin 1999/25 (21) Application number: 98925939.0 (22) Date of filing: 28.05.1998

(51) International Patent Classification (IPC):  C12N 15/ 09( . ) C07K 14/ 435( . ) C07K 14/ 47( . ) C12N 1/ 15( . ) C12N 1/ 21( . ) C12N 15/ 62( . ) C12P 21/ 02( . ) C07K 7/ 08( . ) C07K 14/ 46( . ) C07K 14/ 815( . ) C12N 1/ 19( . ) C12N 5/ 10( . ) C12P 21/ 00( . ) C12R 1/ 19( . ) (86) International application number: PCT/KR1998/000132 (87) International publication number: WO 1998/054336 (03.12.1998 Gazette 1998/48)

(84) Designated Contracting States: DE FR GB IT (30) Priority: 28.05.1997 KR 19210031297 09.04.1998 KR 19130037298 (71) Applicants: Samyang Genex Co., Ltd. Chongno-Ku, Seoul 110-470 (KR) KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY Taejon 305-338 (KR)

(72) Inventors: KIM, Sun-Chang Taejon 305-335 (KR) LEE, Jae, Hyun Taejon 305-590 (KR) KANG, Min, Hyung Seoul 137-064 (KR) KIM, Jeong, Hyun Taejon 305-348 (KR) HONG, Seung-Suh 109-404 Cheonggu-Narae Apartment Yusong-ku Taejon 305-390 (KR) LEE, Hyun-Soo Seoul 137-040 (KR) (74) Representative: Daniels, Jeffrey Nicholas, et al  Page White & Farrer 54 Doughty Street London WC1N 2LS London WC1N 2LS (GB)