(19)
(11) EP 0 925 289 A1

(12)

(43) Date of publication:
30.06.1999 Bulletin 1999/26

(21) Application number: 98940170.0

(22) Date of filing: 07.07.1998
(51) International Patent Classification (IPC): 
A61K 31/ 197( . )
A61K 31/ 40( . )
A61K 31/ 444( . )
A61K 31/ 495( . )
A61P 29/ 00( . )
A61P 43/ 00( . )
C07D 207/ 16( . )
C07D 213/ 40( . )
C07D 213/ 81( . )
C07D 295/ 18( . )
C07D 317/ 68( . )
A61K 31/ 16( . )
A61K 31/ 4433( . )
A61K 31/ 445( . )
A61K 31/ 5375( . )
A61P 35/ 00( . )
C07C 259/ 06( . )
C07D 211/ 58( . )
C07D 213/ 74( . )
C07D 233/ 32( . )
C07D 295/ 185( . )
C07D 405/ 12( . )
(86) International application number:
PCT/EP1998/004220
(87) International publication number:
WO 1999/002510 (21.01.1999 Gazette 1999/03)
(84) Designated Contracting States:
DE ES FR GB IT SE

(30) Priority: 10.07.1997 GB 19970014548
18.11.1997 GB 19970024395

(71) Applicant: PHARMACIA & UPJOHN S.p.A.
20152 Milano (IT)

(72) Inventors:
  • ALPEGIANI, Marco
    I-20132 Milan (IT)
  • BISSOLINO, Pierluigi
    I-27020 San Giorgio di Lomellina (IT)
  • ABRATE, Francesca
    I-20124 Milan (IT)
  • PERRONE, Ettore
    I-20010 Boffalora Ticino (IT)
  • CORIGLI, Riccardo
    I-20148 Milan (IT)
  • JABES, Daniela
    I-20146 Milan (IT)

(74) Representative: Mazzini, Giuseppe 
Pharmacia Italia S.p.A. Patent Department Viale Pasteur 10
20014 Nerviano (MI)
20014 Nerviano (MI) (IT)

   


(54) MATRIX METALLOPROTEINASE INHIBITORS