(19)
(11) EP 0 927 035 A1

(12)

(43) Date of publication:
07.07.1999 Bulletin 1999/27

(21) Application number: 97942415.0

(22) Date of filing: 09.09.1997
(51) International Patent Classification (IPC): 
C07D 295/ 22( . )
A61K 31/ 4409( . )
A61K 31/ 4545( . )
A61P 7/ 02( . )
C07D 213/ 16( . )
C07D 213/ 73( . )
C07D 295/ 26( . )
 A61K 31/ 155( . )
A61K 31/ 443( . )
A61K 31/ 495( . )
C07C 257/ 18( . )
C07D 213/ 30( . )
C07D 213/ 74( . )
C07D 405/ 12( . )
(86) International application number:
PCT/US1997/015989
(87) International publication number:
WO 1998/010763 (19.03.1998 Gazette 1998/11)
(84) Designated Contracting States:
AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

(30) Priority: 13.09.1996 US 19960026033P
22.11.1996 GB 19960024278

(71) Applicant: MERCK & CO., INC.
Rahway, New Jersey 07065 (US)

(72) Inventors:
  • NAYLOR-OLSEN, Adel, M.
    Rahway, NJ 07065 (US)
  • PONTICELLO, Gerald, S.
    Rahway, NJ 07065 (US)
  • VACCA, Joseph, P.
    Rahway, NJ 07065 (US)
  • HUNGATE, Randall, W.
    Rahway, NJ 07065 (US)
  • COBURN, Craig
    Rahway, NJ 07065 (US)
  • PHILLIPS, Brian, T.
    Rahway, NJ 07065 (US)
  • LEWIS, S., D.
    Rahway, NJ 07065 (US)
  • FRALEY, Mark, E.
    Rahway, NJ 07065 (US)

(74) Representative: Horgan, James Michael Frederic, et al 
Merck & Co., Inc., Terlings Park, Eastwick Road
Harlow, Essex CM20 2QR
Harlow, Essex CM20 2QR (GB)

   


(54) THROMBIN INHIBITORS