(19)

(11)

EP 0 927 044 A1

(12)

(43) Date of publication: 07.07.1999 Bulletin 1999/27 (21) Application number: 97918752.0 (22) Date of filing: 15.04.1997

(51) International Patent Classification (IPC):  A61K 48/ 00( . ) C12N 15/ 12( . ) C12N 15/ 864( . ) C07K 16/ 28( . ) C12N 15/ 86( . ) C12N 15/ 867( . ) (86) International application number: PCT/US1997/006590 (87) International publication number: WO 1997/038723 (23.10.1997 Gazette 1997/45)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE (30) Priority: 16.04.1996 US 19960015497P (71) Applicant: IMMUSOL, INC. San Diego, CA 92121 (US)	(72) Inventors: MAMOUNAS, Michael Solana Beach, CA 92075 (US) YU, Gang San Diego, CA 92130 (US) YANG, Qicheng San Diego, CA 92129 (US) LI, Qi-Xiang San Diego, CA 92126 (US) BARBER, Jack San Diego, CA 92128 (US) YU, Mang San Diego, CA 92122 (US) (74) Representative: Kiddle, Simon John, et al  Mewburn Ellis, York House, 23 Kingsway London WC2B 6HP London WC2B 6HP (GB)