(19)

(11)

EP 0 927 182 A2

(12)

(43) Date of publication: 07.07.1999 Bulletin 1999/27 (21) Application number: 97939749.0 (22) Date of filing: 03.09.1997

(51) International Patent Classification (IPC):  A61K 31/ 4353( . ) A61P 29/ 00( . ) A61P 35/ 00( . ) C07D 498/ 18( . ) A61P 11/ 06( . ) A61P 31/ 10( . ) A61P 37/ 06( . ) (86) International application number: PCT/US1997/015439 (87) International publication number: WO 1998/009970 (12.03.1998 Gazette 1998/10)

(84) Designated Contracting States: AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE Designated Extension States: AL LT LV RO SI (30) Priority: 09.09.1996 US 19960709591 (71) Applicant: AMERICAN HOME PRODUCTS CORPORATION Madison, New Jersey 07940-0874 (US)

(72) Inventors: HU, David, Cheng Foster City, CA 94404 (US) GRINFIELD, Alexander, Aleksey Princeton Junction, NJ 08550 (US) CAGGIANO, Thomas, Joseph Morrisville, PA 19067 (US) CAUFIELD, Craig, Eugene Princeton Junction, NJ 08550 (US) (74) Representative: Wileman, David Francis, Dr., et al  c/o Wyeth Laboratories Huntercombe Lane South Taplow Maidenhead Berkshire SL6 OPH Taplow Maidenhead Berkshire SL6 OPH (GB)